中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
1期
47-51
,共5页
王俊薇%任颖%李连喜%邵琦%赵催春%陆志刚%魏盟
王俊薇%任穎%李連喜%邵琦%趙催春%陸誌剛%魏盟
왕준미%임영%리련희%소기%조최춘%륙지강%위맹
非甲状腺病态综合征%非心肌梗死冠心病%远期死亡
非甲狀腺病態綜閤徵%非心肌梗死冠心病%遠期死亡
비갑상선병태종합정%비심기경사관심병%원기사망
Non-thyroidal illness syndrome%Coronary artery disease%Long-term mortality
目的 探讨非心肌梗死冠心病患者中非甲状腺病态综合征(non-thyroidal illness syndrome,NTIS)及FT3水平与远期全因、心血管死亡率的关系.方法 入选1 354例行冠脉造影的患者,经筛选后最终纳入984例经冠脉造影明确诊断的非心肌梗死冠心病患者,分为NTIS组和甲状腺功能正常组,按FT3三分位数(Tertile)分为T1、T2、T3组.研究随访1～6年,采用多因素Cox回归分析,比较FT3水平与非心肌梗死冠心病患者远期全因及心血管死亡率的关系.结果 984例非心肌梗死冠心病患者中129例存在NTIS.远期随访结果显示,随着FT3水平降低,全因死亡率(T1组为9.6％,T2组为11.5％,T3组为20.9％,P＜0.01)及心血管死亡率(T1组为4.5％,T2组为7.2％,T3组为11.0％,P＜0.01)均逐渐增高.经过各因素校正,FT3(HR=0.614,95％ CI0.439 ～0.859)与全因死亡独立相关.FT3(HR=0.605,95％ CI0.370～0.986)也是心血管死亡的独立危险因子.结论 NTIS存在于非心肌梗死冠心病患者,FT3降低为影响非心肌梗死冠心病患者远期全因死亡及心血管死亡的独立危险因素.
目的 探討非心肌梗死冠心病患者中非甲狀腺病態綜閤徵(non-thyroidal illness syndrome,NTIS)及FT3水平與遠期全因、心血管死亡率的關繫.方法 入選1 354例行冠脈造影的患者,經篩選後最終納入984例經冠脈造影明確診斷的非心肌梗死冠心病患者,分為NTIS組和甲狀腺功能正常組,按FT3三分位數(Tertile)分為T1、T2、T3組.研究隨訪1～6年,採用多因素Cox迴歸分析,比較FT3水平與非心肌梗死冠心病患者遠期全因及心血管死亡率的關繫.結果 984例非心肌梗死冠心病患者中129例存在NTIS.遠期隨訪結果顯示,隨著FT3水平降低,全因死亡率(T1組為9.6％,T2組為11.5％,T3組為20.9％,P＜0.01)及心血管死亡率(T1組為4.5％,T2組為7.2％,T3組為11.0％,P＜0.01)均逐漸增高.經過各因素校正,FT3(HR=0.614,95％ CI0.439 ～0.859)與全因死亡獨立相關.FT3(HR=0.605,95％ CI0.370～0.986)也是心血管死亡的獨立危險因子.結論 NTIS存在于非心肌梗死冠心病患者,FT3降低為影響非心肌梗死冠心病患者遠期全因死亡及心血管死亡的獨立危險因素.
목적 탐토비심기경사관심병환자중비갑상선병태종합정(non-thyroidal illness syndrome,NTIS)급FT3수평여원기전인、심혈관사망솔적관계.방법 입선1 354례행관맥조영적환자,경사선후최종납입984례경관맥조영명학진단적비심기경사관심병환자,분위NTIS조화갑상선공능정상조,안FT3삼분위수(Tertile)분위T1、T2、T3조.연구수방1～6년,채용다인소Cox회귀분석,비교FT3수평여비심기경사관심병환자원기전인급심혈관사망솔적관계.결과 984례비심기경사관심병환자중129례존재NTIS.원기수방결과현시,수착FT3수평강저,전인사망솔(T1조위9.6％,T2조위11.5％,T3조위20.9％,P＜0.01)급심혈관사망솔(T1조위4.5％,T2조위7.2％,T3조위11.0％,P＜0.01)균축점증고.경과각인소교정,FT3(HR=0.614,95％ CI0.439 ～0.859)여전인사망독립상관.FT3(HR=0.605,95％ CI0.370～0.986)야시심혈관사망적독립위험인자.결론 NTIS존재우비심기경사관심병환자,FT3강저위영향비심기경사관심병환자원기전인사망급심혈관사망적독립위험인소.
Objective To determine the prognostic significance of non-thyroidal illness syndrome(NTIS) and FT3 on long-term all-cause and cardiovascular mortality in patients with coronary artery disease(CAD).Methods A total of 1 354 patients underwent coronary angiograhy and participated in the study.After screening,984 patients with CAD were enrolled finally and divided into NTIS group and euthyroid group.The admitted patients were also classified into Tertile 1-3 groups based on FT3 value.The relationship of long-term all-cause and cardiovascular mortality with FT3 was investigated by multivariate Cox regression analysis.Results 129 out of 984 patients had NTIS.As FT3 value decreased,both long-term all-cause mortality (Tertile 1 group 9.6％,Tertile 2 group 11.5％,Tertile 3 group 20.9％,P＜0.01) and cardiovascular mortality (Tertile 1 group 4.5 ％,Tertile 2 group 7.2％,Tertile 3 group 11.0％,P＜0.01) gradually increased.After adjusting for all factors,FT3 (HR =0.614,95％ CI 0.439-0.859)was independently associated with long-term all-cause mortality.FT3 (HR =0.605,95％ CI 0.370-0.986)was also a risk factor for cardiovascular mortality.Conclusion NTIS exists in patients with CAD without myocardial infarction.FT3 reduction is an independent risk factor for long-term all-cause and cardiovascular mortality in patients with CAD.
