中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2015年
2期
122-125
,共4页
喻希%葛鹏%王子成%林健
喻希%葛鵬%王子成%林健
유희%갈붕%왕자성%림건
膀胱肿瘤%膀胱切除术%预后%淋巴血管侵犯
膀胱腫瘤%膀胱切除術%預後%淋巴血管侵犯
방광종류%방광절제술%예후%림파혈관침범
Urinary bladder neoplasms%Cystectomy%Prognosis%Lymphovascular invasion
目的 探讨淋巴血管侵犯(lymphovascular invasion,LVI)能否作为接受根治性膀胱切除术的膀胱癌患者的预后指标. 方法 回顾性分析我院2006年1月至2012年12月459例行根治性膀胱切除术膀胱癌患者的临床资料,其中男391例,女68例;病理分级G147例,G2 104例,G3308例;病理分期T1或更低167例,T2 127例,T3 89例,T4 76例;有淋巴结转移92例;随访时间13～99个月;LVI通过对标本进行HE染色来判断.x2检验分析LVI与各临床因素的联系,Kaplan-Meier生存曲线比较有、无LVI患者的无复发生存期,多因素Cox风险比例模型分析根治性膀胱切除术后患者无复发生存期的影响因素. 结果 459例患者中128例(28％)存在LVI,其中44例(34％)肿瘤复发,LVI与性别、肿瘤分级、分期、淋巴结转移和肿瘤复发相关,无LVI患者的无复发生存期长于有LVI者(P＜0.05).多因素分析结果显示,年龄、病理分期和淋巴结转移是肿瘤复发的独立预测因子,LVI并非独立预测因子. 结论 根治性膀胱切除术患者的LVI与其他预后因素有很大的联系,但不能作为肿瘤复发的独立预测因子.
目的 探討淋巴血管侵犯(lymphovascular invasion,LVI)能否作為接受根治性膀胱切除術的膀胱癌患者的預後指標. 方法 迴顧性分析我院2006年1月至2012年12月459例行根治性膀胱切除術膀胱癌患者的臨床資料,其中男391例,女68例;病理分級G147例,G2 104例,G3308例;病理分期T1或更低167例,T2 127例,T3 89例,T4 76例;有淋巴結轉移92例;隨訪時間13～99箇月;LVI通過對標本進行HE染色來判斷.x2檢驗分析LVI與各臨床因素的聯繫,Kaplan-Meier生存麯線比較有、無LVI患者的無複髮生存期,多因素Cox風險比例模型分析根治性膀胱切除術後患者無複髮生存期的影響因素. 結果 459例患者中128例(28％)存在LVI,其中44例(34％)腫瘤複髮,LVI與性彆、腫瘤分級、分期、淋巴結轉移和腫瘤複髮相關,無LVI患者的無複髮生存期長于有LVI者(P＜0.05).多因素分析結果顯示,年齡、病理分期和淋巴結轉移是腫瘤複髮的獨立預測因子,LVI併非獨立預測因子. 結論 根治性膀胱切除術患者的LVI與其他預後因素有很大的聯繫,但不能作為腫瘤複髮的獨立預測因子.
목적 탐토림파혈관침범(lymphovascular invasion,LVI)능부작위접수근치성방광절제술적방광암환자적예후지표. 방법 회고성분석아원2006년1월지2012년12월459례행근치성방광절제술방광암환자적림상자료,기중남391례,녀68례;병리분급G147례,G2 104례,G3308례;병리분기T1혹경저167례,T2 127례,T3 89례,T4 76례;유림파결전이92례;수방시간13～99개월;LVI통과대표본진행HE염색래판단.x2검험분석LVI여각림상인소적련계,Kaplan-Meier생존곡선비교유、무LVI환자적무복발생존기,다인소Cox풍험비례모형분석근치성방광절제술후환자무복발생존기적영향인소. 결과 459례환자중128례(28％)존재LVI,기중44례(34％)종류복발,LVI여성별、종류분급、분기、림파결전이화종류복발상관,무LVI환자적무복발생존기장우유LVI자(P＜0.05).다인소분석결과현시,년령、병리분기화림파결전이시종류복발적독립예측인자,LVI병비독립예측인자. 결론 근치성방광절제술환자적LVI여기타예후인소유흔대적련계,단불능작위종류복발적독립예측인자.
Objective To explore whether lymphovascular invasion can be used as a prognostic indicator in patients with bladder cancer underwent radical cystectomy.Methods The series included clinical data of 459 patients who had underwent radical cystectomy for bladder cancer between January 2006 and December 2012 in our hospital.Among all the patients,391 were male while 68 were female.Pathological grade G1 was diagnosed in 47,G2 in 104 and G3 in 308.Amount of pathological stage T1 or Tis or Ta or T0 was 167,T2 127,T3 89 and T4 76.Of all the patients,92 had lymph node metastasis.Follow-up time was between 13 and 99 months.The presence or absence of lymphovascular invasion was determined by HE staining in the radical cystectomy specimen.The x2 test was used to detect the association between lymphovascular invasion and several clinicopathological features,the Kaplan-Meier method was used to compare recurrence-free survival according to findings of lymphovascular invasion in the surgical specimen,and the multivariate Cox proportional-hazards regression model was used to assess the prognostic significance of some factors.Results Lymphovascular invasion was detected in 128 (28％) specimens.Among them,44 (34％) had tumor recurrence.Lymphovascular invasion was significantly associated with gender,tumor grade,pathological stage,lymph node metastasis and disease recurrence.Recurrence-free survival in patients without lymphovascular invasion was significantly higher than that in those with lymphovascular invasion (P＜ 0.05).Cox proportional hazards model showed that age,pathological stage and lymph node metastasis were independent predictors for disease recurrence.Conclusion In patients with bladder cancer underwent radical cystectomy,lymphovascular invasion may have a significant association with some prognostic parameters,but it can not be used as an independent predictor of disease recurrence.
