中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2015年
2期
144-147
,共4页
勃起功能障碍%夜间阴茎勃起功能监测%代谢综合征%前瞻性研究
勃起功能障礙%夜間陰莖勃起功能鑑測%代謝綜閤徵%前瞻性研究
발기공능장애%야간음경발기공능감측%대사종합정%전첨성연구
Erectile dysfunction%Nocturanl penile tumescence test%Metabolic syndrome%Prospective studies
目的 探讨夜间阴茎勃起功能(nocturnal penile tumescence,NPT)监测结果与代谢综合征(metabolic syndrome,MS)的相关性. 方法 本前瞻性研究从2010年6月至2011年6月入组25例健康志愿者设为A组(健康对照组),入组25例NPT正常的勃起功能障碍(erectile dysfunction,ED)患者设为B组(NPT正常ED组),入组25例NPT异常的ED患者设为C组(NPT异常ED组).入组时3组受试者血清总睾酮均>9.9 nmol/L,并排除MS诊断.入组时3组受试者腰围、体质指数、空腹血糖、平均动脉压、三酰甘油、高密度脂蛋白、总胆固醇及血清总睾酮组间两两比较差异均无统计学意义(P>0.05),B、C两组国际勃起功能评分差异无统计学意义(P>0.05).3年后随访,再次检测以上代谢数据,并比较3组受试者MS的发生率. 结果 3年后随访时,失访者A组2例,B组3例,C组5例.A、B两组各项指标比较差异无统计学意义(P>0.05);A、C两组比较,平均动脉压、空腹血糖、高密度脂蛋白、总胆固醇差异有统计学意义(P<0.05);B、C两组比较,平均动脉压、高密度脂蛋白差异有统计学意义(P<0.05).3年后A组患MS者2例,B组3例,C组7例,3组间MS发病率差异有统计学意义(P<0.05). 结论 NPT结果能在一定程度上反映和预测MS的发生和发展,可作为早期预警MS的参考指标之一,值得注意.
目的 探討夜間陰莖勃起功能(nocturnal penile tumescence,NPT)鑑測結果與代謝綜閤徵(metabolic syndrome,MS)的相關性. 方法 本前瞻性研究從2010年6月至2011年6月入組25例健康誌願者設為A組(健康對照組),入組25例NPT正常的勃起功能障礙(erectile dysfunction,ED)患者設為B組(NPT正常ED組),入組25例NPT異常的ED患者設為C組(NPT異常ED組).入組時3組受試者血清總睪酮均>9.9 nmol/L,併排除MS診斷.入組時3組受試者腰圍、體質指數、空腹血糖、平均動脈壓、三酰甘油、高密度脂蛋白、總膽固醇及血清總睪酮組間兩兩比較差異均無統計學意義(P>0.05),B、C兩組國際勃起功能評分差異無統計學意義(P>0.05).3年後隨訪,再次檢測以上代謝數據,併比較3組受試者MS的髮生率. 結果 3年後隨訪時,失訪者A組2例,B組3例,C組5例.A、B兩組各項指標比較差異無統計學意義(P>0.05);A、C兩組比較,平均動脈壓、空腹血糖、高密度脂蛋白、總膽固醇差異有統計學意義(P<0.05);B、C兩組比較,平均動脈壓、高密度脂蛋白差異有統計學意義(P<0.05).3年後A組患MS者2例,B組3例,C組7例,3組間MS髮病率差異有統計學意義(P<0.05). 結論 NPT結果能在一定程度上反映和預測MS的髮生和髮展,可作為早期預警MS的參攷指標之一,值得註意.
목적 탐토야간음경발기공능(nocturnal penile tumescence,NPT)감측결과여대사종합정(metabolic syndrome,MS)적상관성. 방법 본전첨성연구종2010년6월지2011년6월입조25례건강지원자설위A조(건강대조조),입조25례NPT정상적발기공능장애(erectile dysfunction,ED)환자설위B조(NPT정상ED조),입조25례NPT이상적ED환자설위C조(NPT이상ED조).입조시3조수시자혈청총고동균>9.9 nmol/L,병배제MS진단.입조시3조수시자요위、체질지수、공복혈당、평균동맥압、삼선감유、고밀도지단백、총담고순급혈청총고동조간량량비교차이균무통계학의의(P>0.05),B、C량조국제발기공능평분차이무통계학의의(P>0.05).3년후수방,재차검측이상대사수거,병비교3조수시자MS적발생솔. 결과 3년후수방시,실방자A조2례,B조3례,C조5례.A、B량조각항지표비교차이무통계학의의(P>0.05);A、C량조비교,평균동맥압、공복혈당、고밀도지단백、총담고순차이유통계학의의(P<0.05);B、C량조비교,평균동맥압、고밀도지단백차이유통계학의의(P<0.05).3년후A조환MS자2례,B조3례,C조7례,3조간MS발병솔차이유통계학의의(P<0.05). 결론 NPT결과능재일정정도상반영화예측MS적발생화발전,가작위조기예경MS적삼고지표지일,치득주의.
Objective To investigate the correlation between nocturnal penile tumescence (NPT) test results and metabolic syndrome (MS).Methods In this prospective study,75 cases were enrolled,including 25 healthy volunteers (group A),25 erectile dysfunction (ED) patients with normal NPT results (group B),and 25 ED patients with abnormal NPT results (group C).At the time of recruitment,all the participants had serum total testosterone higher than 9.9 nmol/L,and were free of MS.At baseline,there was no significant differences in waistline,body mass index,fasting plasma glucose (FPG),mean arterial pressure (MAP),triglyceride,high density lipoprotein (HDL),cholesterol,and serum total testosterone among the three groups (P>0.05).And there was no significant difference in international index of erectile function 5 score between group B and C.A follow-up survey was conducted three years after baseline to measure the above metabolic indicators and to compare the incidence of MS among the three groups.Results In the three-year follow-up survey,2 participants in group A were lost to follow-up,compared to 3 participants in group B and 5 participants in group C.In the three-year follow-up survey,there was no significant difference in all the indicators between group A and B; between group A and C,significant differences were observed in MAP,FPG,HDL,and cholesterol (P<0.05); between group B and C,significant differences were observed in MAP and HDL (P<0.05).In the three-year follow-up survey,2 participants in group A developed MS,compared to 3 MS patients in group B and 7 MS patients in group C.There was a significant difference in the incidence of MS among the three groups (P<0.05).Conclusions To some extent,NPT reflects and predicts the development and progress of MS.Therefore,NPT can be used as an early indicator of MS.