CAJ | 학술논문

目的探讨早期未治疗帕金森病(PD)患者非运动症状的分布特点和影响因素. 方法对106例早期未治疗的PD患者及108例对照组进行非运动症状问卷调查,分析非运动症状的分布状况,并分为老年组和非老年组进行比较,其中PD老年组76例,年龄(66.8±6.6)岁,非老年组30例,年龄(57.3±5.2)岁;结合临床特征等因素分析非运动症状发生的主要影响因素. 结果 (1)老年PD组的非运动症状总数(13±7)个和非老年PD组的非运动症状总数(11±4)个,均高于同龄对照组[分别为(4±2)个和(2±1)个],差异有统计学意义(t=10.843、12.145,均P＜0.001).(2)老年PD组非运动症状发生率有20项,而非老年PD组非运动症状发生率有9项,均显著高于同龄对照组,差异有统计学意义(均P＜0.05);各项发生率中老年组以便秘、非老年组以嗅觉障碍的发生率最高.(3)老年PD组非运动症状发生个数与病程(r=0.413)、Hoehn-Yahr分级(r=0.318)和年龄(r=0.385)呈正相关(P＜0.05);非老年PD组非运动症状发生个数与Hoehn-Yahr分级呈正相关(r=0.306,P＜0.05). 结论老年和非老年PD患者的非运动症状发生率均高于同龄对照组;非运动症状普遍存在于早期PD患者,且随着病情的加重及年龄的增长而增多;应提高对非运动症状诊断和合理治疗的重视,才能提高疗效.
목적 탐토조기미치료파금삼병(PD)환자비운동증상적분포특점화영향인소. 방법 대106례조기미치료적PD환자급108례대조조진행비운동증상문권조사,분석비운동증상적분포상황,병분위노년조화비노년조진행비교,기중PD노년조76례,년령(66.8±6.6)세,비노년조30례,년령(57.3±5.2)세;결합림상특정등인소분석비운동증상발생적주요영향인소. 결과 (1)노년PD조적비운동증상총수(13±7)개화비노년PD조적비운동증상총수(11±4)개,균고우동령대조조[분별위(4±2)개화(2±1)개],차이유통계학의의(t=10.843、12.145,균P＜0.001).(2)노년PD조비운동증상발생솔유20항,이비노년PD조비운동증상발생솔유9항,균현저고우동령대조조,차이유통계학의의(균P＜0.05);각항발생솔중노년조이편비、비노년조이후각장애적발생솔최고.(3)노년PD조비운동증상발생개수여병정(r=0.413)、Hoehn-Yahr분급(r=0.318)화년령(r=0.385)정정상관(P＜0.05);비노년PD조비운동증상발생개수여Hoehn-Yahr분급정정상관(r=0.306,P＜0.05). 결론 노년화비노년PD환자적비운동증상발생솔균고우동령대조조;비운동증상보편존재우조기PD환자,차수착병정적가중급년령적증장이증다;응제고대비운동증상진단화합리치료적중시,재능제고료효.
Objective To assess the characteristics and influencing factors of non-motor symptoms (non-motor symptoms) in untreated patients with Parkinson's disease (PD) at early stage.Methods A total of 106 untreated patients with PD at early stage and 108 healthy controls (HC) matched for age,gender,education status and occupation were investigated by non-motor symptoms questionnaire.And both of them were divided into two groups:aged group (≥60 years old) and nonaged group (＜60 years old).76 cases with an average of (66.8±6.6) years old were selected in the aged group,and 30 cases with an average of (57.3± 5.2) years old were selected in the non-aged group.The distribution of non-motor symptoms items was analyzed between two groups.The clinical characteristics of PD patients were also collected to assess the dominant influencing factors for the prevalence of non-motor symptoms.Results The total number of non-motor symptoms was significantly higher in aged PD patients and non aged PD patients than in age-matched control groups [(13±7) vs.(4±2),t=10.843; (11±4) vs.(2±1),t=12.145,both P＜0.001].The incidence of non-motor symptoms was significantly higher in aged PD patients (20 items) and non-aged PD patients (9 items) than in age-matched control groups (both P＜0.05).The constipation in aged PD patients and the olfactory disturbance in non-aged PD patients were the most frequent ones.The number of non motor symptoms was positively correlated with course of disease(r=0.413),age(r=0.385) and Hoehn-Yahr stage (r =0.318) in aged PD patients (all P ＜ 0.05).The number of non motor symptoms was positively correlated with Hoehn-Yahr stage in non-aged PD patients (r=0.306,P＜0.05).Conclusions non-motor symptoms are more frequently seen in aged and non-aged PD patients than in age-matched controls.non-motor symptoms are more common in PD patients at earl stage and the number of non-motor symptoms increases with the degree of disease severity and age.More attention should be paid to the diagnosis and rational treatment of the non-motor symptoms so as to increase treatment effectiveness.