中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
1期
73-77
,共5页
张亚莉%冯婕%李燕%张文静%袁美群%冯学亮
張亞莉%馮婕%李燕%張文靜%袁美群%馮學亮
장아리%풍첩%리연%장문정%원미군%풍학량
肾病综合征%肾小球肾炎,膜增生性
腎病綜閤徵%腎小毬腎炎,膜增生性
신병종합정%신소구신염,막증생성
Nephritic syndrome%Glomerulonephritis,Membranoproliferative
目的 了解老年人特发性膜性肾病的临床病理特点及其关系. 方法 回顾性分析我院近10年诊断为特发性膜性肾病老年患者(年龄≥60岁,老年组)的临床及病理资料,并与同期特发性膜性肾病非老年患者(年龄<60岁,对照组)的资料进行比较. 结果 老年组及对照组均以男性多见,分别占57.4%和59.2%,两组在性别构成方面差异无统计学意义(x2=0.254,P>0.05);老年组及对照组特发性膜性肾病占同期同年龄原发性肾小球疾病比分别为42.8%和17.4%(x2=119.058,P<0.01).老年组病程、水肿、高血压、血尿素氮、血肌酐、血中IgG、IgA及IgG/IgM比值均高于对照组,而肾小球滤过率、血IgM低于对照组,差异均有统计学意义(P<0.05).老年组疾病危险度明显高于对照组,差异有统计学意义(Z=-5.853,P<0.01).临床诊断两组均以肾病综合征常见,但老年组肾病综合征较对照组更常见,差异有统计学意义(x2=6.825,P=0.033<0.05);两组均以Ⅱ期及以下的膜性肾病常见,在病理分期以及临床表现与病理分期间的关系差异无统计学意义(P>0.05). 结论 (1)老年组及对照组特发性膜性病男性多于女性;(2)老年患者以Ⅱ期及以下膜性肾病常见,老年患者疾病危险度高;(3)老年患者易发生水肿、高血压及肾功能异常.
目的 瞭解老年人特髮性膜性腎病的臨床病理特點及其關繫. 方法 迴顧性分析我院近10年診斷為特髮性膜性腎病老年患者(年齡≥60歲,老年組)的臨床及病理資料,併與同期特髮性膜性腎病非老年患者(年齡<60歲,對照組)的資料進行比較. 結果 老年組及對照組均以男性多見,分彆佔57.4%和59.2%,兩組在性彆構成方麵差異無統計學意義(x2=0.254,P>0.05);老年組及對照組特髮性膜性腎病佔同期同年齡原髮性腎小毬疾病比分彆為42.8%和17.4%(x2=119.058,P<0.01).老年組病程、水腫、高血壓、血尿素氮、血肌酐、血中IgG、IgA及IgG/IgM比值均高于對照組,而腎小毬濾過率、血IgM低于對照組,差異均有統計學意義(P<0.05).老年組疾病危險度明顯高于對照組,差異有統計學意義(Z=-5.853,P<0.01).臨床診斷兩組均以腎病綜閤徵常見,但老年組腎病綜閤徵較對照組更常見,差異有統計學意義(x2=6.825,P=0.033<0.05);兩組均以Ⅱ期及以下的膜性腎病常見,在病理分期以及臨床錶現與病理分期間的關繫差異無統計學意義(P>0.05). 結論 (1)老年組及對照組特髮性膜性病男性多于女性;(2)老年患者以Ⅱ期及以下膜性腎病常見,老年患者疾病危險度高;(3)老年患者易髮生水腫、高血壓及腎功能異常.
목적 료해노년인특발성막성신병적림상병리특점급기관계. 방법 회고성분석아원근10년진단위특발성막성신병노년환자(년령≥60세,노년조)적림상급병리자료,병여동기특발성막성신병비노년환자(년령<60세,대조조)적자료진행비교. 결과 노년조급대조조균이남성다견,분별점57.4%화59.2%,량조재성별구성방면차이무통계학의의(x2=0.254,P>0.05);노년조급대조조특발성막성신병점동기동년령원발성신소구질병비분별위42.8%화17.4%(x2=119.058,P<0.01).노년조병정、수종、고혈압、혈뇨소담、혈기항、혈중IgG、IgA급IgG/IgM비치균고우대조조,이신소구려과솔、혈IgM저우대조조,차이균유통계학의의(P<0.05).노년조질병위험도명현고우대조조,차이유통계학의의(Z=-5.853,P<0.01).림상진단량조균이신병종합정상견,단노년조신병종합정교대조조경상견,차이유통계학의의(x2=6.825,P=0.033<0.05);량조균이Ⅱ기급이하적막성신병상견,재병리분기이급림상표현여병리분기간적관계차이무통계학의의(P>0.05). 결론 (1)노년조급대조조특발성막성병남성다우녀성;(2)노년환자이Ⅱ기급이하막성신병상견,노년환자질병위험도고;(3)노년환자역발생수종、고혈압급신공능이상.
Objective To understand the clinical and pathological characteristics of idiopathic membranous nephropathy,and to investigate their relationships in the elderly patients.Methods The clinical and pathological data of idiopathic membranous nephropathy diagnosed by renal biopsy in the recently 10 years in our hospital were retrospectively analyzed and compared.Results Sex composition variable was not significant between elderly and non-elderly groups,with male accounting for 57.4% and 59.2% respectively (P>0.05).The ratio of idiopathic membranous nephropathy in primary glomerular disease was higher in the elderly than in non-elderly group (42.8% vs.17.4%,x2 =119.058,P<0.01).The course of the disease,the occurrence of edema,hypertension,levels of blood urea nitrogen,serum creatinine,blood IgG,IgA and IgG/IgM ratio were higher,while glomerular filtration rate and blood IgM level were lower in elderly group than in non-elderly group (all P<0.05).The risk for membranous nephropathy was higher in elderly than in non-elderly group (Z=-5.853,P<0.01).Nephrotic syndrome was common in the clinical diagnosis in the two groups,but it was more common in elderly group than in non-elderly group (x2 =6.825,P=0.033).Membranous nephropathy stage Ⅱ was common in the two groups,and there were no significant differences in the pathological stages,clinical manifestations and their relationships between the two groups (all P>0.05).Conclusions The risk for idiopathic membranous nephropathy is higher in elderly group than in non-elderly group.Edema,hypertension and renal dysfunction occur more commonly in elderly patients with idiopathic membranous nephropathy.