中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
CHINESE JOURNAL OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2015年
1期
20-24
,共5页
杭伟%刘钢%韩彤%张佩兰%张金玲
杭偉%劉鋼%韓彤%張珮蘭%張金玲
항위%류강%한동%장패란%장금령
帕金森病%嗅觉障碍%嗅球%嗅通路%磁共振成像
帕金森病%嗅覺障礙%嗅毬%嗅通路%磁共振成像
파금삼병%후각장애%후구%후통로%자공진성상
Parkinson disease%Olfaction disorders%Olfactory bulb%Olfactory pathways%Megnetic resonance imaging
目的 分析原发性帕金森病患者嗅球体积、嗅沟深度与嗅觉功能的相关性.方法 选取2011年1月至2013年12月天津市环湖医院原发性帕金森病患者(测试组)及无运动障碍的健康受试者(对照组)各100例,应用T&T嗅觉测试法检查所有受试者的嗅觉功能,并行嗅球体积、嗅沟深度的MRI检查及测量.对测试组进行H-Y分期、统一帕金森病评分量表(UPDRS)、左右肢体功能评分、简易精神状态检查表(MMSE)及蒙特利尔认知评估表(MoCA)检查.以SPSS 13.0软件进行统计学分析.结果 测试组T&T嗅觉识别阈分数为(3.0±0.3)分,明显高于对照组的(1.3±0.2)分,差异有统计学意义(t=2.537,P＜0.01),测试组、对照组男女嗅觉识别阈差异无统计学意义(t值分别为0.893、1.184,P值均＞0.05).测试组左右两侧嗅球体积[分别为(34.25 ±5.14)、(35.79±5.28)mm3]及平均嗅球体积[(35.28±5.21) mm3]均明显小于对照组[分别为(47.38±6.47)、(47.75 ±6.51)、(47.53±6.49)mm3],差异有统计学意义(t值分别为2.876、2.747、2.798,P值均＜0.01).测试组与对照组左右两侧嗅沟深度及平均嗅沟深度差异无统计学意义(t值分别为0.914、0.987、0.951,P值均＞0.05).测试组及对照组嗅觉识别阈与平均嗅球体积呈负相关趋势(r值分别为-0.537、-0.526,P值均＜0.05),与平均嗅沟深度无关(r值分别为-0.142,-0.157,P值均＞0.05).测试组平均嗅球体积与UPDRSⅢ、UPDRS总评分及H-Y分期具有相关趋势(r值分别为0.312、-0.419、-0.358,P值均＜0.05),与病程无相关性(r=-0.089,P＞0.05).结论 原发性帕金森病患者嗅球体积减小,嗅沟深度不变;其嗅觉功能与嗅球体积具有相关性,与嗅沟深度无关;其嗅觉减退的程度与疾病的严重程度具有一致性,与疾病的病程无关.
目的 分析原髮性帕金森病患者嗅毬體積、嗅溝深度與嗅覺功能的相關性.方法 選取2011年1月至2013年12月天津市環湖醫院原髮性帕金森病患者(測試組)及無運動障礙的健康受試者(對照組)各100例,應用T&T嗅覺測試法檢查所有受試者的嗅覺功能,併行嗅毬體積、嗅溝深度的MRI檢查及測量.對測試組進行H-Y分期、統一帕金森病評分量錶(UPDRS)、左右肢體功能評分、簡易精神狀態檢查錶(MMSE)及矇特利爾認知評估錶(MoCA)檢查.以SPSS 13.0軟件進行統計學分析.結果 測試組T&T嗅覺識彆閾分數為(3.0±0.3)分,明顯高于對照組的(1.3±0.2)分,差異有統計學意義(t=2.537,P＜0.01),測試組、對照組男女嗅覺識彆閾差異無統計學意義(t值分彆為0.893、1.184,P值均＞0.05).測試組左右兩側嗅毬體積[分彆為(34.25 ±5.14)、(35.79±5.28)mm3]及平均嗅毬體積[(35.28±5.21) mm3]均明顯小于對照組[分彆為(47.38±6.47)、(47.75 ±6.51)、(47.53±6.49)mm3],差異有統計學意義(t值分彆為2.876、2.747、2.798,P值均＜0.01).測試組與對照組左右兩側嗅溝深度及平均嗅溝深度差異無統計學意義(t值分彆為0.914、0.987、0.951,P值均＞0.05).測試組及對照組嗅覺識彆閾與平均嗅毬體積呈負相關趨勢(r值分彆為-0.537、-0.526,P值均＜0.05),與平均嗅溝深度無關(r值分彆為-0.142,-0.157,P值均＞0.05).測試組平均嗅毬體積與UPDRSⅢ、UPDRS總評分及H-Y分期具有相關趨勢(r值分彆為0.312、-0.419、-0.358,P值均＜0.05),與病程無相關性(r=-0.089,P＞0.05).結論 原髮性帕金森病患者嗅毬體積減小,嗅溝深度不變;其嗅覺功能與嗅毬體積具有相關性,與嗅溝深度無關;其嗅覺減退的程度與疾病的嚴重程度具有一緻性,與疾病的病程無關.
목적 분석원발성파금삼병환자후구체적、후구심도여후각공능적상관성.방법 선취2011년1월지2013년12월천진시배호의원원발성파금삼병환자(측시조)급무운동장애적건강수시자(대조조)각100례,응용T&T후각측시법검사소유수시자적후각공능,병행후구체적、후구심도적MRI검사급측량.대측시조진행H-Y분기、통일파금삼병평분량표(UPDRS)、좌우지체공능평분、간역정신상태검사표(MMSE)급몽특리이인지평고표(MoCA)검사.이SPSS 13.0연건진행통계학분석.결과 측시조T&T후각식별역분수위(3.0±0.3)분,명현고우대조조적(1.3±0.2)분,차이유통계학의의(t=2.537,P＜0.01),측시조、대조조남녀후각식별역차이무통계학의의(t치분별위0.893、1.184,P치균＞0.05).측시조좌우량측후구체적[분별위(34.25 ±5.14)、(35.79±5.28)mm3]급평균후구체적[(35.28±5.21) mm3]균명현소우대조조[분별위(47.38±6.47)、(47.75 ±6.51)、(47.53±6.49)mm3],차이유통계학의의(t치분별위2.876、2.747、2.798,P치균＜0.01).측시조여대조조좌우량측후구심도급평균후구심도차이무통계학의의(t치분별위0.914、0.987、0.951,P치균＞0.05).측시조급대조조후각식별역여평균후구체적정부상관추세(r치분별위-0.537、-0.526,P치균＜0.05),여평균후구심도무관(r치분별위-0.142,-0.157,P치균＞0.05).측시조평균후구체적여UPDRSⅢ、UPDRS총평분급H-Y분기구유상관추세(r치분별위0.312、-0.419、-0.358,P치균＜0.05),여병정무상관성(r=-0.089,P＞0.05).결론 원발성파금삼병환자후구체적감소,후구심도불변;기후각공능여후구체적구유상관성,여후구심도무관;기후각감퇴적정도여질병적엄중정도구유일치성,여질병적병정무관.
Objective To analyze the correlation between olfactory bulb(OB) volume with depth of olfactory sulcus(OS) and olfactory function in patients with idiopathic Parkinson's disease (IPD).Methods One hundred patients with IPD between January 2011 to December 2013 in Tianjin Huanhu Hospotal were compared with one hundred controls in terms of olfactory function T&T testing,OB volume and depth of OS assessed with Magnetic resonance imaging (MRI).One hundred IPD patients were investigated and estimated H-Y degrees,UPDRS,MMSE,MoCA.SPSS 13.0 software was used to analyze the data.Results T&T olfactory testing revealed that IPD patients (3.0 ± 0.3) had higher scores than controls(1.3 ± 0.2,t =2.537,P＜0.01).Both men and women with IPD were affected by the same extent of olfactory loss(t =0.893,P ＞ 0.05).Both men and women as controls were affected by the same extent of olfactory loss(t =1.184,P ＞ 0.05).OB volume of left side in IPD patients was (34.25 ± 5.14) mm3,right side was (35.79 ±5.28)mm3,average OB volume was (35.28 ±5.21)mm3 ; OB volume of left side in controls was (47.38 ± 6.47) mm3,right side was (47.75 ± 6.51) mm3,average OB volume was (47.53 ± 6.49)mm3 ; OB volume were lower in IPD patients as compared to controls(t value were 2.876,2.747,2.798,all P ＜ 0.01).OS depth study revealed no statistical difference between IPD patients and controls (t value were 0.914,0.987,0.951,all P ＞ 0.05).Olfactory discriminate threshold was negatively correlated with average OB volume in IPD patients and controls(r value were-0.537,-0.526,both P ＜ 0.05) ; was no correlated with average depth of OS(r value were-0.142,-0.157,both P ＞ 0.05).There was relation between the average OB volume and UPDRS Ⅲ,UPDRS,the degree of H-Y in IPD patients(r value were 0.312,-0.419,-0.358,all P ＜0.05).However the average OB volume was not related to the course of disease(r =-0.089,P ＞ 0.05).Conclusions The OB volume is lower in IPD patients as compared to controls,the depth of OS have no significant changes in IPD patients; The OB volume is correlated with olfactory function,the depth of OS is not correlated with olfactory function ; Olfactory function lower degree is accordance with serious degree in IPD patients,is not accordance with the course of disease.
