CAJ | 학술논문

目的了解多巴胺D2受体(DRD2)基因rs1079727多态性与学龄儿童注意分散度的关系.方法运用Carey 8～ 12岁MCTQ儿童气质问卷、自动化MassArray SNP基因型分型技术、单因素方差分析和Logistic回归分析法,分析121例8～12岁儿童的注意分散度与DRD2基因rs1079727多态性的相关性,重点探讨了性别、分娩方式与基因交互作用对注意分散度的影响.结果 DRD2基因rs1079727多态性、分娩方式均与儿童注意分散度明显相关,GG和AG基因型儿童的注意分散度分值[分别为(4.37±0.53)分,(4.27±0.69)分]高于AA基因型儿童(4.01±0.67)分,剖宫产儿童注意分散度高分组比例(48.28％)高于顺产儿童(33.90％),均差异有统计学意义(P＜0.05);rs1079727多态性与性别、rs1079727多态性与分娩方式的交互作用均对儿童注意分散度有影响,G等位基因会增加女孩发生注意分散的风险(OR值为2.231,P＜0.05),顺产时A等位基因对儿童注意分散度具有一定保护作用(OR值为0.048,P＜0.01),差异均有统计学意义.结论分娩方式、rs1079727多态性及其与性别/分娩方式的交互作用共同作用于注意分散度.
목적 료해다파알D2수체(DRD2)기인rs1079727다태성여학령인동주의분산도적관계.방법 운용Carey 8～ 12세MCTQ인동기질문권、자동화MassArray SNP기인형분형기술、단인소방차분석화Logistic회귀분석법,분석121례8～12세인동적주의분산도여DRD2기인rs1079727다태성적상관성,중점탐토료성별、분면방식여기인교호작용대주의분산도적영향.결과 DRD2기인rs1079727다태성、분면방식균여인동주의분산도명현상관,GG화AG기인형인동적주의분산도분치[분별위(4.37±0.53)분,(4.27±0.69)분]고우AA기인형인동(4.01±0.67)분,부궁산인동주의분산도고분조비례(48.28％)고우순산인동(33.90％),균차이유통계학의의(P＜0.05);rs1079727다태성여성별、rs1079727다태성여분면방식적교호작용균대인동주의분산도유영향,G등위기인회증가녀해발생주의분산적풍험(OR치위2.231,P＜0.05),순산시A등위기인대인동주의분산도구유일정보호작용(OR치위0.048,P＜0.01),차이균유통계학의의.결론 분면방식、rs1079727다태성급기여성별/분면방식적교호작용공동작용우주의분산도.
Objective To understand the association between rs1079727 polymorphism in the DRD2 gene and the distractibility in the school-age children.Method The rs1079727 polymorphisms were genotyped using Sequenom Mass Array and the distractibility was measured based on the Middle Childhood Temperament Questionnaire (MCTQ) in 121 children aged from 8 to 12 years,in order to analyze the function of rs1079727 polymorphism and its interaction with gender or the delivery mode on the distractibility.The results were analyzcd with oneway ANOVA and logistic regression analysis.Results There was association between the distractibility and rs1079727 polymorphism or delivery mode respectively.The means of distractibility for the genotypes of GG (4.37 ±0.53) and AG (4.27±0.69) were significantly higher than that of the genotype of AA(4.01±0.67) (P＜0.05).The proportion of high distractibility in the cesarean children (48.28％) was significantly higher than that in the natural labor children (33.90％) (P＜0.05).The child distractibility occurred through an interaction between rs1079727 polymorphism and gender/delivery mode.The girls with G alleles possessed increased risk of distractibility (OR=2.231,P＜0.05),and the natural labor children with A alleles were tend to be associated with low distractibility(OR =0.048,P＜0.01).Condusion The distractibility based the temperament for the school-age children might be influenced by delivery mode,rs1079727 polymorphism and its interaction with gender/delivery mode.