中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
12期
1095-1098
,共4页
张书友%孙剑%余海鹰%陈方斌%张理义
張書友%孫劍%餘海鷹%陳方斌%張理義
장서우%손검%여해응%진방빈%장리의
视黄醇结合蛋白4%非酒精性脂肪肝病%精神分裂症%代谢综合征
視黃醇結閤蛋白4%非酒精性脂肪肝病%精神分裂癥%代謝綜閤徵
시황순결합단백4%비주정성지방간병%정신분렬증%대사종합정
Retinol-binding protein 4%Non-alcoholic fatty liver disease%Schizophrenia%Metabolic syndrome
目的 对精神分裂症伴发非酒精性脂肪肝(NAFLD)患者血清视黄醇结合蛋白4(RBP4)水平进行对照研究,探讨RBP4与NAFLD的关系.方法 测定服用奥氮平的精神分裂症伴NAFLD患者(病例组,n=60)和不伴NAFLD患者(对照组,n=60)血清RBP4、及代谢综合征组分包括体质量指数(BMI)、腰臀比(WHR)、空腹血糖(FPG)、胆固醇(TC)及甘油三酯(TG)、血压;以TyG指数评价胰岛素抵抗;肝/脾CT比值诊断及评估NAFLD严重程度.结果 病例组RBP4水平较对照组增高[(70±13) mg/L vs(52±12) mg/L,t=4.943,P＜0.01),调整影响因素后差异仍有统计学意义(F=16.797,P＜0.01);TyG指数、BMI、WHR、FPG、TC、TG、舒张压也高于对照组,差异有统计学意义(t=2.383～4.300,P＜0.05或0.01).重、中度NAFLD患者RBP4水平高于轻度患者,差异有统计学意义[(79±16)mg/L、(72±8) mg/L vs(63±9) mg/L,d=16.2,9.9,P＜0.01或0.05];病例组RBP4水平与肝/脾CT比值负相关(r=-0.244,P＜0.05),与TyG指数、BMI、WHR、TG正相关(r=0.197～ 0.244,均P＜0.05);调整影响因素后,RBP4水平与肝/脾CT比值仍呈负相关(r=-0.453,P＜0.01).Logistic回归分析示RBP4水平增高与NAFLD发生有关(β=0.105,P＜0.01),TyG指数增高、血脂异常、肥胖症、中心性肥胖、血压增高也与NAFLD有关(β=1.288～9.711,P＜0.05或0.01).结论 血清RBP4水平升高可能是精神分裂症患者发生NAFLD的危险因素之一.
目的 對精神分裂癥伴髮非酒精性脂肪肝(NAFLD)患者血清視黃醇結閤蛋白4(RBP4)水平進行對照研究,探討RBP4與NAFLD的關繫.方法 測定服用奧氮平的精神分裂癥伴NAFLD患者(病例組,n=60)和不伴NAFLD患者(對照組,n=60)血清RBP4、及代謝綜閤徵組分包括體質量指數(BMI)、腰臀比(WHR)、空腹血糖(FPG)、膽固醇(TC)及甘油三酯(TG)、血壓;以TyG指數評價胰島素牴抗;肝/脾CT比值診斷及評估NAFLD嚴重程度.結果 病例組RBP4水平較對照組增高[(70±13) mg/L vs(52±12) mg/L,t=4.943,P＜0.01),調整影響因素後差異仍有統計學意義(F=16.797,P＜0.01);TyG指數、BMI、WHR、FPG、TC、TG、舒張壓也高于對照組,差異有統計學意義(t=2.383～4.300,P＜0.05或0.01).重、中度NAFLD患者RBP4水平高于輕度患者,差異有統計學意義[(79±16)mg/L、(72±8) mg/L vs(63±9) mg/L,d=16.2,9.9,P＜0.01或0.05];病例組RBP4水平與肝/脾CT比值負相關(r=-0.244,P＜0.05),與TyG指數、BMI、WHR、TG正相關(r=0.197～ 0.244,均P＜0.05);調整影響因素後,RBP4水平與肝/脾CT比值仍呈負相關(r=-0.453,P＜0.01).Logistic迴歸分析示RBP4水平增高與NAFLD髮生有關(β=0.105,P＜0.01),TyG指數增高、血脂異常、肥胖癥、中心性肥胖、血壓增高也與NAFLD有關(β=1.288～9.711,P＜0.05或0.01).結論 血清RBP4水平升高可能是精神分裂癥患者髮生NAFLD的危險因素之一.
목적 대정신분렬증반발비주정성지방간(NAFLD)환자혈청시황순결합단백4(RBP4)수평진행대조연구,탐토RBP4여NAFLD적관계.방법 측정복용오담평적정신분렬증반NAFLD환자(병례조,n=60)화불반NAFLD환자(대조조,n=60)혈청RBP4、급대사종합정조분포괄체질량지수(BMI)、요둔비(WHR)、공복혈당(FPG)、담고순(TC)급감유삼지(TG)、혈압;이TyG지수평개이도소저항;간/비CT비치진단급평고NAFLD엄중정도.결과 병례조RBP4수평교대조조증고[(70±13) mg/L vs(52±12) mg/L,t=4.943,P＜0.01),조정영향인소후차이잉유통계학의의(F=16.797,P＜0.01);TyG지수、BMI、WHR、FPG、TC、TG、서장압야고우대조조,차이유통계학의의(t=2.383～4.300,P＜0.05혹0.01).중、중도NAFLD환자RBP4수평고우경도환자,차이유통계학의의[(79±16)mg/L、(72±8) mg/L vs(63±9) mg/L,d=16.2,9.9,P＜0.01혹0.05];병례조RBP4수평여간/비CT비치부상관(r=-0.244,P＜0.05),여TyG지수、BMI、WHR、TG정상관(r=0.197～ 0.244,균P＜0.05);조정영향인소후,RBP4수평여간/비CT비치잉정부상관(r=-0.453,P＜0.01).Logistic회귀분석시RBP4수평증고여NAFLD발생유관(β=0.105,P＜0.01),TyG지수증고、혈지이상、비반증、중심성비반、혈압증고야여NAFLD유관(β=1.288～9.711,P＜0.05혹0.01).결론 혈청RBP4수평승고가능시정신분렬증환자발생NAFLD적위험인소지일.
Objective To investigate the serum retinol-binding protein 4 (RBP4) level in olanzapinetreated schizophrenia with non-alcoholic fatty liver disease (NAFLD) via a case-control study and to explore its relationship with NAFLD.Methods Schizophrenia receiving olanzapine treatment,with or without NAFLD were enrolled as cases (n=60) or controls (n=60).The serum retinol-binding protein 4,metabolic syndrome component including body mass index (BMI),waist-to-hip ratio (WHR),fasting plasma glucose (FPG),total cholesterol (TG),total glycerin (TC) and blood pressure were assayed.TyG index,CT value ratio of liver and spleen were used for insulin resistance or NAFLD diagnosis and severity assessment respectively.Results The serum level of RBP4 was significantly higher in cases than that in controls ((70± 13)mg/L vs (52±12)mg/L ; t =4.943,P＜0.01) and the same result was showed after influencing factor adjustment thru covariance analysis (F=16.797,P＜0.01).Moreover,cases had significantly higher TyG index,BMI,WHR,FPG,TG and systolic pressure (t=2.383-4.300,P＜0.05-0.01).Cases with severe or moderate NAFLD had significantly elevated serum RBP4 level compared with mild cases((79± 16) mg/L,(72±8) mg/L vs (63t9) mg/L,d =16.2,9.9 ; P＜0.01,0.05).A significantly negative correlation between RBP4 level and the CT value ratio of liver and spleen (r=-0.244,P＜0.05),and a significantly positive correlation between RBP4 level and TyG index,BMI,WHR,TG(r=0.197-0.244,all P＜0.05) were observed.The partial coefficient between RBP4 level and CT value of liver and spleen was significant with influence adjusted(r=-0.453,P＜0.01).Logistic regression showed that serum RBP4 level(β3=0.105,P＜0.01)and TyG index,hyperlipidemia,obesity,central obesity or high blood pressure (β =1.288-9.711,P＜ 0.05-0.01) were closely associated with NAFLD.Conclusion A heighten serum RBP4 level may be one of NAFLD risk factors in schizophrenia treated with olanzapine.
