中华眼视光学与视觉科学杂志
中華眼視光學與視覺科學雜誌
중화안시광학여시각과학잡지
CHINESE JOURNAL OF OPTOMETRY OPHTHALMOLOGY AND VISUAL SCIENCE
2014年
12期
741-744
,共4页
蔺波%燕振国%李军%李辰%杨侃
藺波%燕振國%李軍%李辰%楊侃
린파%연진국%리군%리신%양간
儿童%弱视%大脑皮质%磁共振成像
兒童%弱視%大腦皮質%磁共振成像
인동%약시%대뇌피질%자공진성상
Children%Amblyopia%Cerebral cortex%Magnetic resonance imaging
目的 采用3.0 T功能磁共振成像(fMRI)技术,评价屈光不正性弱视儿童在规范弱视训练后,脑皮层视觉运动觉功能区的恢复情况.方法 前瞻性研究.初诊屈光不正性弱视患儿9例,组块式设计,弱视治疗1周、2周及4周时复查fMRI.视觉刺激选择对比度接近100％的8 Hz圆环形旋转棋盘格.采用基于Matlab 7.12的SPM8软件包对数据进行离线处理,利用假设驱动法获得每个治疗阶段的矩阵数据,采用配对t检验对治疗前后各组视皮层功能区激活的程度进行比较.结果 弱视训练2周后,双侧枕叶(右侧BA18区Mean t=1.236 1;左侧BA18区Mean t=1.521 1;右侧BA19区Mean t=1.684 5;左侧BA19区Mean t=1.591 7,P＜0.005)较1周时激活强度增加;视觉联合区,即V5区(右侧BA37区Meant=1.201 4;右侧BA21区Mean t=1.1450,P＜0.005)开始激活,至第4周时,激活范围及程度较2周时下降(右侧BA18区Mean t=1.002 4;左侧BA18区Mean t=1.743 1;右侧BA19区Mean t=1.225 3;左侧BA19区Mean t=1.181 3,P＜0.005).结论 大龄儿童屈光不正性弱视功能训练早期,重建视中枢视觉运动觉的功能较困难,且不稳定.
目的 採用3.0 T功能磁共振成像(fMRI)技術,評價屈光不正性弱視兒童在規範弱視訓練後,腦皮層視覺運動覺功能區的恢複情況.方法 前瞻性研究.初診屈光不正性弱視患兒9例,組塊式設計,弱視治療1週、2週及4週時複查fMRI.視覺刺激選擇對比度接近100％的8 Hz圓環形鏇轉棋盤格.採用基于Matlab 7.12的SPM8軟件包對數據進行離線處理,利用假設驅動法穫得每箇治療階段的矩陣數據,採用配對t檢驗對治療前後各組視皮層功能區激活的程度進行比較.結果 弱視訓練2週後,雙側枕葉(右側BA18區Mean t=1.236 1;左側BA18區Mean t=1.521 1;右側BA19區Mean t=1.684 5;左側BA19區Mean t=1.591 7,P＜0.005)較1週時激活彊度增加;視覺聯閤區,即V5區(右側BA37區Meant=1.201 4;右側BA21區Mean t=1.1450,P＜0.005)開始激活,至第4週時,激活範圍及程度較2週時下降(右側BA18區Mean t=1.002 4;左側BA18區Mean t=1.743 1;右側BA19區Mean t=1.225 3;左側BA19區Mean t=1.181 3,P＜0.005).結論 大齡兒童屈光不正性弱視功能訓練早期,重建視中樞視覺運動覺的功能較睏難,且不穩定.
목적 채용3.0 T공능자공진성상(fMRI)기술,평개굴광불정성약시인동재규범약시훈련후,뇌피층시각운동각공능구적회복정황.방법 전첨성연구.초진굴광불정성약시환인9례,조괴식설계,약시치료1주、2주급4주시복사fMRI.시각자격선택대비도접근100％적8 Hz원배형선전기반격.채용기우Matlab 7.12적SPM8연건포대수거진행리선처리,이용가설구동법획득매개치료계단적구진수거,채용배대t검험대치료전후각조시피층공능구격활적정도진행비교.결과 약시훈련2주후,쌍측침협(우측BA18구Mean t=1.236 1;좌측BA18구Mean t=1.521 1;우측BA19구Mean t=1.684 5;좌측BA19구Mean t=1.591 7,P＜0.005)교1주시격활강도증가;시각연합구,즉V5구(우측BA37구Meant=1.201 4;우측BA21구Mean t=1.1450,P＜0.005)개시격활,지제4주시,격활범위급정도교2주시하강(우측BA18구Mean t=1.002 4;좌측BA18구Mean t=1.743 1;우측BA19구Mean t=1.225 3;좌측BA19구Mean t=1.181 3,P＜0.005).결론 대령인동굴광불정성약시공능훈련조기,중건시중추시각운동각적공능교곤난,차불은정.
Objective To research the recovery of the visual cortical function mediating visual motion perception in ametropic amblyopia after regular amblyopia treatment using 3.0 Tesla functional MRI (fMRI).Methods In this prospective study,blocks-designed fMRI experiment was performed on nine children with first was diagnosed as ametropic amblyopia,and review fMRI after one week,two weeks and one month.During the study,the patients were asked to view stimuli through rotating the checkerboard,which contrast ratio approach to 100％ and frequency approach to 8 Hz,Functional MRI data were processed by using SPM8 which based on the Matlab 7.12.The matrix data of each treatment stage were acquired bv hypothesisdriven research,and before and after self-control study (matched t-test) was performed in each group to acquire average cerebral cortex activated functional images data.The different mapping between each group during visual motion stimulus was also acquired.Results The functional area that is bilateral occipital lobe (Mean t of the right BA18=1.236 1 ;Mean t of the left BA18=1.521 1; Mean t of the right BA19=1.6845; Mean t of the left BA19=1.591 7,P＜0.005) and the visual association area (V5) (The right BA37 was activated and Mean T=1.201 4;The right BA21 was activated and Mean t=1.145 0,P＜0.005) expanded in different levels after amblyopia treatment two weeks; After four weeks,the bilateral occipital lobe (Mean t of the right BA18=1.0024; Mean t of the left BA18=1.743 1; Mean t of the right BA19=1.2253; Mean t of the left BA19=1.181 3,P＜0.005) showed activation on the small area compare with two weeks ago.Conclusion In the early functional training of the older children's ametropic amblyopia,reconstruction the visual cortical function mediating visual motion perception was more difficulty and unstable.
