CAJ | 학술논문

肿瘤组织中存在的肿瘤干细胞是肿瘤转移和复发的根源,而转化生长因子-β1(TGF-β1)在肿瘤干细胞的增殖分化过程中有着重要的调节作用,目前在许多肿瘤包括乳腺癌、肝癌、胰腺癌、肺癌、胶质瘤、胆囊癌等的肿瘤组织中发现,TGF-β1诱导的上皮间质转化(EMT)能够抑制肿瘤细胞增殖,同时富集肿瘤干细胞,增加肿瘤的侵袭和耐药能力.
종류조직중존재적종류간세포시종류전이화복발적근원,이전화생장인자-β1(TGF-β1)재종류간세포적증식분화과정중유착중요적조절작용,목전재허다종류포괄유선암、간암、이선암、폐암、효질류、담낭암등적종류조직중발현,TGF-β1유도적상피간질전화(EMT)능구억제종류세포증식,동시부집종류간세포,증가종류적침습화내약능력.
Tumor stem cells are responsible for metastasis and relapse of cancer.Transforming growth factor-β1 (TGF-β1) plays an important role in the proliferation and differentiation of tumor stem cells.In many cancers such as breast carcinoma,hepatocellular carcinoma,pancreatic carcinoma,lung carcinoma,glioma and gallbladder carcinoma,the epithelial-mesenchymal transition (EMT) induced by TGF-β1 can inhibit proliferation of cancer cell,enrich tumor stem cells and increase invasive capability and drug resistance of cancer.