CAJ | 학술논문

肿瘤干细胞是一类具有自我更新、分化和高度致瘤能力的细胞亚群,其与肿瘤的发生、发展、复发以及治疗抵抗等密切相关,而其中最重要的特性是自我更新能力.深入研究肿瘤干细胞的自我更新调控机制,对于开发以肿瘤干细胞为靶点的新型靶向治疗药物具有重要意义.
종류간세포시일류구유자아경신、분화화고도치류능력적세포아군,기여종류적발생、발전、복발이급치료저항등밀절상관,이기중최중요적특성시자아경신능력.심입연구종류간세포적자아경신조공궤제,대우개발이종류간세포위파점적신형파향치료약물구유중요의의.
Cancer stem cells comprise a sub-population with the capacity of self-renewal,self-differentiation and high tumorigenicity.Cancerogenesis,development,relapse and therapeutic resistance are closely related with these cells.The most important characteristics of these cells are the ability to self-renew.So insight into the regulating mechanism of self-renewal in cancer stem cells will be important for the development of novel molecular agents targeted the cancer stem cells.