CAJ | 학술논문

血管生成拟态(VM)是一种肿瘤细胞通过自身变形并模拟产生血管样通道而达到自身血液供应的方式.胶质瘤中VM的形成与胶质瘤干细胞关系密切,另外一些分子如微小RNA(miRNA)、上皮细胞激酶(EphA2)、血管内皮钙黏蛋白(VE-cadherin)、转化生长因子-β(TGF-β)、血管内皮细胞生长因子受体-2(VEGFR-2)、凝集素1(Gal1)等在胶质瘤VM形成过程中也发挥重要作用.VM与胶质瘤患者的预后不良及其抗血管药物疗效不佳密切相关,所以针对VM形成机制、预后影响以及临床意义的研究将为胶质瘤的早期诊断和治疗提供新思路和可能的新靶点.
혈관생성의태(VM)시일충종류세포통과자신변형병모의산생혈관양통도이체도자신혈액공응적방식.효질류중VM적형성여효질류간세포관계밀절,령외일사분자여미소RNA(miRNA)、상피세포격매(EphA2)、혈관내피개점단백(VE-cadherin)、전화생장인자-β(TGF-β)、혈관내피세포생장인자수체-2(VEGFR-2)、응집소1(Gal1)등재효질류VM형성과정중야발휘중요작용.VM여효질류환자적예후불량급기항혈관약물료효불가밀절상관,소이침대VM형성궤제、예후영향이급림상의의적연구장위효질류적조기진단화치료제공신사로화가능적신파점.
Vasculogenic mimicry (VM) is a pattern of neoplasm cells,which achieve their blood supplements through deformation and simulating capillary channels.Cumulative studies show that the formation of VM in glioma have a close relation with the glioma stem cells.In addition,some molecules such as microRNA,epithelial cell kinase-A2,vascular endothelial cadherin,transforming growth factor-Jβ,vascular endothelial growth factor receptor-2 and galectin-1 play important roles in the forming process of vasculogenic mimicry.Recently,it is found that VM is associated with the poor prognosis of patients with glioma and anti angiogenesis drug efficacy.So the research on VM about the discovery,formation mechanism,prognostic impact and the clinical significance will provide an opportunity for diagnosis and therapy of glioma in early stage.