国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2015年
1期
18-21
,共4页
郝志强%李晓凤%于德东%白雪峰
郝誌彊%李曉鳳%于德東%白雪峰
학지강%리효봉%우덕동%백설봉
卵巢肿瘤%基因%B7-H1%Bcl-2%免疫组织化学
卵巢腫瘤%基因%B7-H1%Bcl-2%免疫組織化學
란소종류%기인%B7-H1%Bcl-2%면역조직화학
Ovarian neoplasms%Gene%B7-H1%Bcl-2%Immunohistochemistry
目的 探讨B7-H1与Bcl-2在上皮性卵巢癌组织中的表达及其与上皮性卵巢癌临床病理特征之间的关系.方法 应用免疫组织化学法检测手术切除的80例上皮性卵巢癌组织及20例正常卵巢组织蜡块中B7-H1及Bcl-2的表达情况,并分析其表达与不同临床病理特征之间的相关性.结果 上皮性卵巢癌组织B7-H1及Bcl-2阳性表达率分别为77.5％ (62/80)和58.8％ (47/80),均高于正常卵巢组织的15.0％ (3/20)和10.0％ (2/20),差异有统计学意义(x2=27.473,P＜0.05;x2=15.216,P＜0.05).Bcl-2及B7-H1在上皮性卵巢癌组织中的表达均与分化程度呈负相关(x2=9.367,P＜0.01;x2=11.702,P＜0.01),而且Bcl-2与国际妇产科联合会分期呈正相关(x2=7.766,P＜0.01).另外,在上皮性卵巢癌组织中B7-H1和Bcl-2阳性表达之间呈正相关(r =0.400,P＜0.01).结论 B7-H1和Bcl-2在上皮性卵巢癌组织中表达明显上调,二者存在正相关性,与上皮性卵巢癌的发生、发展有关,联合检测B7-H1和Bcl-2可能对上皮性卵巢癌的诊治有一定的指导作用.
目的 探討B7-H1與Bcl-2在上皮性卵巢癌組織中的錶達及其與上皮性卵巢癌臨床病理特徵之間的關繫.方法 應用免疫組織化學法檢測手術切除的80例上皮性卵巢癌組織及20例正常卵巢組織蠟塊中B7-H1及Bcl-2的錶達情況,併分析其錶達與不同臨床病理特徵之間的相關性.結果 上皮性卵巢癌組織B7-H1及Bcl-2暘性錶達率分彆為77.5％ (62/80)和58.8％ (47/80),均高于正常卵巢組織的15.0％ (3/20)和10.0％ (2/20),差異有統計學意義(x2=27.473,P＜0.05;x2=15.216,P＜0.05).Bcl-2及B7-H1在上皮性卵巢癌組織中的錶達均與分化程度呈負相關(x2=9.367,P＜0.01;x2=11.702,P＜0.01),而且Bcl-2與國際婦產科聯閤會分期呈正相關(x2=7.766,P＜0.01).另外,在上皮性卵巢癌組織中B7-H1和Bcl-2暘性錶達之間呈正相關(r =0.400,P＜0.01).結論 B7-H1和Bcl-2在上皮性卵巢癌組織中錶達明顯上調,二者存在正相關性,與上皮性卵巢癌的髮生、髮展有關,聯閤檢測B7-H1和Bcl-2可能對上皮性卵巢癌的診治有一定的指導作用.
목적 탐토B7-H1여Bcl-2재상피성란소암조직중적표체급기여상피성란소암림상병리특정지간적관계.방법 응용면역조직화학법검측수술절제적80례상피성란소암조직급20례정상란소조직사괴중B7-H1급Bcl-2적표체정황,병분석기표체여불동림상병리특정지간적상관성.결과 상피성란소암조직B7-H1급Bcl-2양성표체솔분별위77.5％ (62/80)화58.8％ (47/80),균고우정상란소조직적15.0％ (3/20)화10.0％ (2/20),차이유통계학의의(x2=27.473,P＜0.05;x2=15.216,P＜0.05).Bcl-2급B7-H1재상피성란소암조직중적표체균여분화정도정부상관(x2=9.367,P＜0.01;x2=11.702,P＜0.01),이차Bcl-2여국제부산과연합회분기정정상관(x2=7.766,P＜0.01).령외,재상피성란소암조직중B7-H1화Bcl-2양성표체지간정정상관(r =0.400,P＜0.01).결론 B7-H1화Bcl-2재상피성란소암조직중표체명현상조,이자존재정상관성,여상피성란소암적발생、발전유관,연합검측B7-H1화Bcl-2가능대상피성란소암적진치유일정적지도작용.
Objective To investigate the expressions of B7-H1 and Bcl-2 proteins in epithelial ovarian cancer,and to explore the association of the expressions of B7-H1 and Bcl-2 with clinicopathological features.Methods The expressions of B7-H1 and Bcl-2 proteins were detected by immunohistochemistry in 80 cases of epithelial ovarian cancer tissues and 20 normal ovary tissues.The association of the expressions of B7-H1 and Bcl-2 with the clinicopathological features was analyzed.Results The positive expression rates of B7-H1 and Bcl-2 in epithelial ovarian cancer tissues were 77.5％ (62/80) and 58.8％ (47/80),both higher than 15.0％ (3/20) and 10.0％ (2/20) in normal ovary tissues with significant difference (x2 =27.473,P ＜ 0.05 ; x2 =15.216,P ＜ 0.05).Both of Bcl-2 and B7-H1 expressions in epithelial ovarian cancer tissues were negatively correlated with the differentiation degree of epithelial ovarian cancer (x2 =9.367,P ＜ 0.01 ; x2 =11.702,P ＜ 0.01).The Bcl-2 expression in epithelial ovarian cancer tissues was positively correlated with the FIGO stage (x2 =7.766,P ＜ 0.01).The expression of B7-H1 was positively correlated with the expression of Bcl-2 in epithelial ovarian cancer (r =0.400,P ＜0.01).Conclusion The expressions of B7-H1 and Bcl-2 are up-regulated in epithelial ovarian cancer and they correlate to each other positively.The expressions of B7-H1 and Bcl-2 are correlated with the invasion and metastasis of epithelial ovarian cancer.The detection of B7-H1 combined with Bcl-2 may have an important clinical significance in the diagnosis and treatment for patients with epithelial ovarian cancer.
