CAJ | 학술논문

Tbx3(T-box3)基因作为T-box家族的成员之一,广泛存在于人体的多种组织和器官中,参与了胚胎时期乳腺、四肢、心脏、眼、肺、胰腺的发育调控,并且在维持胚胎干细胞的发育中发挥了重要作用.最新研究表明,Tbx3可以作为转录因子通过上皮间质转化、肿瘤干细胞和甲基化等多种途径参与肿瘤的发生和发展.更好地了解Tbx3将为肿瘤的基因诊断和靶向治疗提供新的思路.
Tbx3(T-box3)기인작위T-box가족적성원지일,엄범존재우인체적다충조직화기관중,삼여료배태시기유선、사지、심장、안、폐、이선적발육조공,병차재유지배태간세포적발육중발휘료중요작용.최신연구표명,Tbx3가이작위전록인자통과상피간질전화、종류간세포화갑기화등다충도경삼여종류적발생화발전.경호지료해Tbx3장위종류적기인진단화파향치료제공신적사로.
As a member of T-box family,Tbx3 (T-box3) is widely expressed in multiple organs and involves in the development of breast,limb,heart,eye,lung and pancreas during embryonic development stage.Moreover,Tbx3 plays an important role in maintaining the embryonic stem cells.Recent studies show that Tbx3 can work as a transcription factor to participate in the initiation and progression of tumor by epithelialmesenchymal transition,induction tumor stemness and methylation.A better understanding of Tbx3 will provide new insights into genetic diagnosis and targeted treatment of tumor.