CAJ | 학술논문

Ⅲ类去乙酰化酶Sirtuin 1(SIRT1)是一种依赖NAD+的组蛋白去乙酰化酶.研究发现SIRT1在肿瘤中的作用具有双面性,它可通过抑制炎症、肿瘤血管形成及与肿瘤相关基因相互作用等机制抑制肿瘤的发生发展;也可通过调控肿瘤相关基因、上皮间质转化、促进肿瘤细胞增殖和肿瘤放化疗耐受以及维持肿瘤干细胞的存活等机制促进肿瘤的增殖、侵袭和转移.
Ⅲ류거을선화매Sirtuin 1(SIRT1)시일충의뢰NAD+적조단백거을선화매.연구발현SIRT1재종류중적작용구유쌍면성,타가통과억제염증、종류혈관형성급여종류상관기인상호작용등궤제억제종류적발생발전;야가통과조공종류상관기인、상피간질전화、촉진종류세포증식화종류방화료내수이급유지종류간세포적존활등궤제촉진종류적증식、침습화전이.
Sirtuin 1 (SIRT1),the Ⅲ class deacetylation enzyme,is a kind of NAD + dependent histone deacetylation enzyme.The role of SIRT1 in tumor has the duality.It can inhibit inflammation,tumor angiogenesis and interact with tumor related gene to inhibit tumor development.However,it can also regulate tumor related genes,and epithelial-mesenchymal transition,promote tumor cell proliferation and tolerance of radiotherapy and chemotherapy,and maintain the stemness of cancer stem cells to promote tumor proliferation,invasion and metastasis.