CAJ | 학술논문

目的探讨β-catenin和c-Myc在原发性口腔鳞癌(OSCC)中的表达及意义.方法用免疫组化法检测口腔鳞癌及癌旁正常组织中3-catenin和c-Myc的表达.结果 β-catenin在口腔鳞癌、相应癌旁正常组织中异常表达率分别为56.92％、15.38％,两组之间差异具有统计学意义(P =0.006),β-catenin异常表达增多与肿瘤大小(P=0.003)、局部的淋巴结转移密切相关(P=0.017).在口腔鳞癌、相应癌旁正常组织中c-Myc的阳性表达率为64.62％,7.69％,两组之间差异具有统计学意义(P=0).β-catenin在胞质的表达与c-Myc的表达呈正相关(rs =0.237,P=0.049).结论 c-Myc在口腔鳞癌中过表达,作为原癌基因促进肿瘤发生;β-catenin胞浆异常表达可能与口腔鳞癌的侵袭转移有关.
목적 탐토β-catenin화c-Myc재원발성구강린암(OSCC)중적표체급의의.방법 용면역조화법검측구강린암급암방정상조직중3-catenin화c-Myc적표체.결과 β-catenin재구강린암、상응암방정상조직중이상표체솔분별위56.92％、15.38％,량조지간차이구유통계학의의(P =0.006),β-catenin이상표체증다여종류대소(P=0.003)、국부적림파결전이밀절상관(P=0.017).재구강린암、상응암방정상조직중c-Myc적양성표체솔위64.62％,7.69％,량조지간차이구유통계학의의(P=0).β-catenin재포질적표체여c-Myc적표체정정상관(rs =0.237,P=0.049).결론 c-Myc재구강린암중과표체,작위원암기인촉진종류발생;β-catenin포장이상표체가능여구강린암적침습전이유관.
Objective The purpose of this study was to investigate the expression of β-catenin and c-Myc in oral squamous cell carcinomas (OSCC).Methods The expression of β-Catenin and C-myc was analyzed in 65 OSCC cases and 13 normal oral tissues by immunohistochemistry.Results The abnormal expression rate of β-Catenin was 56.92％ in OSCC tissues,which was significantly higher than that in normal tissues (15.38％,P =0.006).The expression of β-catenin was closely related with tumor size and lymph node metastasis (P =0.003,P =0.017,respectively).The expression rate of c-Myc was 64.62％ in OSCC tissues,which was significantly higher than that in normal tissues (7.69％,P =0).Furthermore,we found that the expression of β-Catenin in cytoplasm was positively correlated with the expression of c-Myc protein in OSCC (rs =0.237,P =0.049).Conclusion Overexpression of c-Myc may play an important role in the development and progression of OSCC,and the expression of β-catenin in cytoplasm was associated with the metastasis of OSCC.