CAJ | 학술논문

宿主遗传背景是人类免疫缺陷病毒(HIV)感染机体后个体间表型差异的主要影响因素之一.它不仅影响HIV易感性,而且影响获得性免疫缺陷综合征(AIDS)进程.全基因组关联研究(GWAS)是一种在全基因组范围内检测与疾病相关基因的技术方法.目前,共有22项与HIV/AIDS相关的GWAS,发现了多个与HIV感染及AIDS进程相关的易感基因和位点.这些结果对研究宿主遗传背景在HIV感染中的作用、AIDS进程的预测及疫苗的研发都有重要意义.本文将对HIV/AIDS的遗传背景及其相关的GWAS作一综述.
숙주유전배경시인류면역결함병독(HIV)감염궤체후개체간표형차이적주요영향인소지일.타불부영향HIV역감성,이차영향획득성면역결함종합정(AIDS)진정.전기인조관련연구(GWAS)시일충재전기인조범위내검측여질병상관기인적기술방법.목전,공유22항여HIV/AIDS상관적GWAS,발현료다개여HIV감염급AIDS진정상관적역감기인화위점.저사결과대연구숙주유전배경재HIV감염중적작용、AIDS진정적예측급역묘적연발도유중요의의.본문장대HIV/AIDS적유전배경급기상관적GWAS작일종술.
The host genetic background is one of major factors which influence the different phenotypes between individuals infected Human Immunodeficiency Virus (HIV).It influences not only the susceptibility to HIV,but also the process of Acquired Immune Deficiency Syndrome (AIDS).Genomewide association studies (GWAS) is a method which detect disease-related genes within genome-wide.Currently,there are 22 GWAS focus on HIV/AIDS and have found a number of susceptibility genes and loci which associated with HIV infection and AIDS progression.The results are important for studies the role of host genetic background in HIV infection,AIDS progression and vaccine research.The host genetic background of HIV/AIDS and associated GWAS are reviewed.