国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2014年
12期
827-831
,共5页
宋以宁%季洪亮%刘倩%柴玉林
宋以寧%季洪亮%劉倩%柴玉林
송이저%계홍량%류천%시옥림
升麻属%乳腺肿瘤%受体,雌激素%治疗学
升痳屬%乳腺腫瘤%受體,雌激素%治療學
승마속%유선종류%수체,자격소%치료학
Cimicifuga%Breast neoplasms%Receptors,estrogen%Therapeutics
目的 探讨黑升麻是否可以通过非雌激素通路改善乳腺癌化疗患者的类更年期症状.方法 选取2012年1月-2013年6月在哈尔滨医科大学4个附属医院诊治的乳腺癌女性患者,年龄20～51岁,术前未停经,且月经规律,术后行规律按时化疗,化疗后Kupperman评分≥15分的120例患者.对所有患者进行随机双盲均分为两组,每组均60例,实验组口服黑升麻提取物药物莉芙敏40 mg每天一次,对照组口服安慰剂(德国SchaPer&Brümmer)40 mg每天一次,服药前和服药12周后对所有患者行雌激素、妇科超声、健侧乳腺超声检测、Kupperman评分,评判其疗效.结果 服药前后实验组与对照组雌激素、子宫内膜的厚度均在正常范围,且差异没有统计学意义(P＞0.05);服药后实验组与对照组健侧乳腺组织均没有发现新肿块.服药后,实验组Kupperman评分比服药前明显降低,差异有统计学意义(P＜0.05);对照组Kupperman评分与服药前相比差异没有统计学意义(P＞0.05).5例实验组的患者服药后Kupperman≥15分,但是均比服药前的评分低.结论 黑升麻可以通过非雌激素通路改善乳腺癌化疗患者的类更年期症状,无论雌激素受体阳性还是阴性,都有较好的疗效.
目的 探討黑升痳是否可以通過非雌激素通路改善乳腺癌化療患者的類更年期癥狀.方法 選取2012年1月-2013年6月在哈爾濱醫科大學4箇附屬醫院診治的乳腺癌女性患者,年齡20～51歲,術前未停經,且月經規律,術後行規律按時化療,化療後Kupperman評分≥15分的120例患者.對所有患者進行隨機雙盲均分為兩組,每組均60例,實驗組口服黑升痳提取物藥物莉芙敏40 mg每天一次,對照組口服安慰劑(德國SchaPer&Brümmer)40 mg每天一次,服藥前和服藥12週後對所有患者行雌激素、婦科超聲、健側乳腺超聲檢測、Kupperman評分,評判其療效.結果 服藥前後實驗組與對照組雌激素、子宮內膜的厚度均在正常範圍,且差異沒有統計學意義(P＞0.05);服藥後實驗組與對照組健側乳腺組織均沒有髮現新腫塊.服藥後,實驗組Kupperman評分比服藥前明顯降低,差異有統計學意義(P＜0.05);對照組Kupperman評分與服藥前相比差異沒有統計學意義(P＞0.05).5例實驗組的患者服藥後Kupperman≥15分,但是均比服藥前的評分低.結論 黑升痳可以通過非雌激素通路改善乳腺癌化療患者的類更年期癥狀,無論雌激素受體暘性還是陰性,都有較好的療效.
목적 탐토흑승마시부가이통과비자격소통로개선유선암화료환자적류경년기증상.방법 선취2012년1월-2013년6월재합이빈의과대학4개부속의원진치적유선암녀성환자,년령20～51세,술전미정경,차월경규률,술후행규률안시화료,화료후Kupperman평분≥15분적120례환자.대소유환자진행수궤쌍맹균분위량조,매조균60례,실험조구복흑승마제취물약물리부민40 mg매천일차,대조조구복안위제(덕국SchaPer&Brümmer)40 mg매천일차,복약전화복약12주후대소유환자행자격소、부과초성、건측유선초성검측、Kupperman평분,평판기료효.결과 복약전후실험조여대조조자격소、자궁내막적후도균재정상범위,차차이몰유통계학의의(P＞0.05);복약후실험조여대조조건측유선조직균몰유발현신종괴.복약후,실험조Kupperman평분비복약전명현강저,차이유통계학의의(P＜0.05);대조조Kupperman평분여복약전상비차이몰유통계학의의(P＞0.05).5례실험조적환자복약후Kupperman≥15분,단시균비복약전적평분저.결론 흑승마가이통과비자격소통로개선유선암화료환자적류경년기증상,무론자격소수체양성환시음성,도유교호적료효.
Objective To investigate whether black cohosh could be improve patients with breast cancer treated chemotherapy like-menopausal symptoms through a non-estrogen pathway.Methods We selected 120 patients with breast cancer dianosised and treated chemotherapy from January 2012 to June 2013 in four Affiliated Hospital of Harbin Medical,which were female patients,20-51 years,preoperative menopause,menstrual regularly,postoperative chemotherapy timely and regularly,and Kupperman score ≥ 15 points.All patients were randomized,double-blind divided into two groups,the experimental group was treated with medication Li Fumin Black Cohosh Extract,40 mg once daily,the other one was treated with placebo,40mg once a day.After 12 weeks,all patients were checked by estrogen hormones,gynecological ultrasound,the ultrasound of the other breast,Kupperman score,Then we make an assessment with those.Results During the experimental group and the control group,estrogen and endometrial thickness were within normal range,and there are not statistically significant difference between before and after medicine(P ＞ 0.05).What's more,before and after medication,the experimental group and the control group were not found new breast lumps.After taking medicine,the Kupperman score of experimental group was significantly lower than before treatment,the difference was statistically significant (P ＜0.05); however,there was not statistically significant difference between before and after medicine for the Kupperman score in control group(P ＞ 0.05).In experimental group,there are 5 cases of patients,which Kupperman is more 15 points,but lower than the score before taking medicine.Conclusions Black cohosh could improve like-menopausal symptoms of patients with breast cancer treated chemotherapy through a non-estrogen pathway,regardless of estrogen-receptor positive or negative,which has a good effection.
