CAJ | 학술논문

甲真菌病顽固难治,目前采用的治疗方法包括局部治疗、口服抗真菌药物治疗以及口服药物和局部治疗等综合疗法,但这些方法的疗效常受多种因素的影响.影响甲真菌病预后的因素主要有甲的局部因素,包括甲真菌病的临床类型、甲板生长速度、甲板厚度、甲母质受累、甲下癣菌瘤或甲下条索状损害的影响,另外还有甲的既往感染史,遗传因素,药物的选择以及糖尿病、银屑病的影响等.其中甲的局部改变是影响预后的最主要因素.充分了解影响甲真菌病的预后因素有助于临床医生确定治疗方案以及随访时间的长度,从而有助于提高甲真菌病的治愈率,改善患者生活质量.
갑진균병완고난치,목전채용적치료방법포괄국부치료、구복항진균약물치료이급구복약물화국부치료등종합요법,단저사방법적료효상수다충인소적영향.영향갑진균병예후적인소주요유갑적국부인소,포괄갑진균병적림상류형、갑판생장속도、갑판후도、갑모질수루、갑하선균류혹갑하조색상손해적영향,령외환유갑적기왕감염사,유전인소,약물적선택이급당뇨병、은설병적영향등.기중갑적국부개변시영향예후적최주요인소.충분료해영향갑진균병적예후인소유조우림상의생학정치료방안이급수방시간적장도,종이유조우제고갑진균병적치유솔,개선환자생활질량.
Onychomycosis is very hard to treat,and present therapeutic approaches include local treatment and oral antifungal treatment alone or in combination.Unfortunately,the treatment outcome is usually influenced by multiple factors.The prognosis of onychomycosis is mainly affected by local factors of nails,including clinical type of onychomycosis,growth rate and thickness of nail plate,involvement of nail matrix,coexistence of subungual dermatophytoma or streak-like lesions.Other prognostic factors include a history of prior nail infection,hereditary factors,choice of drugs,comorbidities such as diabetes or psoriasis,etc.Fully understanding of prognostic factors for onychomycosis can help clinicians to determine treatment protocols and length of follow-up,so as to improve recovery rate and life quality of patients with onychomycosis.