CAJ | 학술논문

聚(ADP-核糖)聚合酶-1[poly(ADP-ribose)polymerase-1,PARP-1]是一种广泛存在于真核细胞内的核酶,在维持基因组稳定和调节基因转录等多种生理学过程中发挥着重要作用.PARP-1在缺血性脑损伤后过度激活,而PARP-1基因敲除小鼠或PARP-1抑制剂能在多种脑缺血模型中减轻脑损伤.因此,PARP-1在缺血性脑损伤的病理生理学过程中发挥着重要作用.探讨PARP-1在脑缺血中的作用,有助于进一步认识卒中的病理生理学机制以及发现新的治疗靶点.
취(ADP-핵당)취합매-1[poly(ADP-ribose)polymerase-1,PARP-1]시일충엄범존재우진핵세포내적핵매,재유지기인조은정화조절기인전록등다충생이학과정중발휘착중요작용.PARP-1재결혈성뇌손상후과도격활,이PARP-1기인고제소서혹PARP-1억제제능재다충뇌결혈모형중감경뇌손상.인차,PARP-1재결혈성뇌손상적병리생이학과정중발휘착중요작용.탐토PARP-1재뇌결혈중적작용,유조우진일보인식졸중적병리생이학궤제이급발현신적치료파점.
Poly (ADP-ribose) polymerase-1 (PARP-1) is a ribozyme that widely exists in the cukaryotic cells.It plays important roles in the maintenance of genomic stability and the regulation of gene transcription and other physiological processes.PARP-1 is overactivated after ischemic brain injury,and PARP-1 gene knockout mice or PARP-1 inhibitor can reduce brain injury in a variety of models of cerebral ischemia.Therefore,PARP-1 plays important roles in the pathophysiologic processes of ischemic brain injury.The investigation of the effect of PARP-1 in cerebral ischemia contributes to further understanding the pathophysiologic mechanism of stroke and finding a new therapeutic target.