国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2014年
12期
907-910
,共4页
么宪伟%于志军%李滟岚%莫翠英%潘红珊%李春阳
麽憲偉%于誌軍%李滟嵐%莫翠英%潘紅珊%李春暘
요헌위%우지군%리염람%막취영%반홍산%리춘양
卒中%抑郁障碍%舍曲林%治疗结果%阿戈美拉汀
卒中%抑鬱障礙%捨麯林%治療結果%阿戈美拉汀
졸중%억욱장애%사곡림%치료결과%아과미랍정
Stroke%Depressive Disorder%Sertraline%Treatment Outcome%Agomelatine
目的 探讨阿戈美拉汀治疗老年卒中后抑郁(post-stroke depression,PSD)的有效性和安全性.方法 80例老年PSD患者随机分为阿戈美拉汀组和舍曲林组,在治疗前和治疗后第1、2、4、6周分别应用汉密尔顿抑郁量表(Hamilton Depression Scale,HMD)、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)和B3arthel指数进行评价.结果 阿戈美拉汀组(n=38)和舍曲林组(n =42)HAMD、NIHSS和Barthel指数评分均随着时间的推移显著改善(P均＜0.001).阿戈美拉汀组与舍曲林组HAMD和NIHSS评分在治疗后不同时间点组间无显著性差异,而Barthel指数评分从治疗后第4周开始出现显著性差异(P均＜0.05).结论 阿戈美拉汀治疗PSD的疗效与舍曲林相当,且其改善日常生活能力的效果优于舍曲林,两者安全性均良好.
目的 探討阿戈美拉汀治療老年卒中後抑鬱(post-stroke depression,PSD)的有效性和安全性.方法 80例老年PSD患者隨機分為阿戈美拉汀組和捨麯林組,在治療前和治療後第1、2、4、6週分彆應用漢密爾頓抑鬱量錶(Hamilton Depression Scale,HMD)、美國國立衛生研究院卒中量錶(National Institutes of Health Stroke Scale,NIHSS)和B3arthel指數進行評價.結果 阿戈美拉汀組(n=38)和捨麯林組(n =42)HAMD、NIHSS和Barthel指數評分均隨著時間的推移顯著改善(P均＜0.001).阿戈美拉汀組與捨麯林組HAMD和NIHSS評分在治療後不同時間點組間無顯著性差異,而Barthel指數評分從治療後第4週開始齣現顯著性差異(P均＜0.05).結論 阿戈美拉汀治療PSD的療效與捨麯林相噹,且其改善日常生活能力的效果優于捨麯林,兩者安全性均良好.
목적 탐토아과미랍정치료노년졸중후억욱(post-stroke depression,PSD)적유효성화안전성.방법 80례노년PSD환자수궤분위아과미랍정조화사곡림조,재치료전화치료후제1、2、4、6주분별응용한밀이돈억욱량표(Hamilton Depression Scale,HMD)、미국국립위생연구원졸중량표(National Institutes of Health Stroke Scale,NIHSS)화B3arthel지수진행평개.결과 아과미랍정조(n=38)화사곡림조(n =42)HAMD、NIHSS화Barthel지수평분균수착시간적추이현저개선(P균＜0.001).아과미랍정조여사곡림조HAMD화NIHSS평분재치료후불동시간점조간무현저성차이,이Barthel지수평분종치료후제4주개시출현현저성차이(P균＜0.05).결론 아과미랍정치료PSD적료효여사곡림상당,차기개선일상생활능력적효과우우사곡림,량자안전성균량호.
Objeetive To investigate the effectiveness and safety of agomelatine for the treatment of elderly patients with post-stroke depression.Methods A total 80 elderly patients with post-stroke depression were randomly divided into either an agomelatine group or a sertraline group.The Hamilton Depression Scale (HAMD),National Institutes of Health Stroke Scale (NIHSS) and Barthel Index were used to evaluate the patients before and after 1,2,4,and 6 weeks,respectively.Results HAMD,NIHSS,and Barthel index scores were improved significantly after treatment in the agomelatine group (n =38) and the sertraline group (n =42).There were significant improvement in the scores of HAMD,NIHSS and Barthel Index with time in both groups (all P ＜0.001).There were no significant difference in the scores of HAMD and NIHSS at different time points after treatment between the agomelatine group and the sertraline group,and the Barthel Index scores began to have significance difference from the fourth week after treatment (all P ＜ 0.05).Conclusions The efficacy of agomelatine for the treatment of PSD is almost the same as sertraline,and the effect of improving activities of daily living is better than sertraline.The safety of both agomelatine and sertraline is good.
