国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2015年
1期
37-41
,共5页
罗莉%黄安兰%施文剑%彭娜%刘抗寒
囉莉%黃安蘭%施文劍%彭娜%劉抗寒
라리%황안란%시문검%팽나%류항한
肾病综合征%HMGB1蛋白质
腎病綜閤徵%HMGB1蛋白質
신병종합정%HMGB1단백질
Nephritic Syndrome%HMGB1 Protein
目的 探讨血清中肿瘤坏死样凋亡微弱诱导剂(TNF-like weak inducer of apoptosis,TWEAK)、高迁移率族蛋白-1(high mobility group box-1,HMGB-1)及核因子-κB(nuclear factor-kappa B,NF-κB)与原发性肾病综合征(primary nephritic syndrome,PNS)的关系.方法 采用酶联免疫吸附法(ELISA)检测46例PNS患者及30例健康体检者血清中TWEAK、HMGB-1及NF-κB的浓度,收集两组的临床资料,进行统计学分析.结果 PNS患者血清中TWEAK、HMGB-1及NF-κB的表达水平均显著高于健康对照组(P＜0.01),TWEAK、HMGB-1及NF-κB、CRP的表达相互之间呈正相关(P＜0.01),并与尿蛋白、总胆固醇、甘油三酯、低密度脂蛋白、CRP之间呈正相关(P＜0.01),与血清白蛋白之间呈负相关(P＜0.01).结论 TWEAK、HMGB-1、NF-κB在PNS中表达水平上调,且相互呈正相关.推测血清TWEAK、HMGB-1可能通过激活NF-κB信号通路在PNS发病中发挥了作用.
目的 探討血清中腫瘤壞死樣凋亡微弱誘導劑(TNF-like weak inducer of apoptosis,TWEAK)、高遷移率族蛋白-1(high mobility group box-1,HMGB-1)及覈因子-κB(nuclear factor-kappa B,NF-κB)與原髮性腎病綜閤徵(primary nephritic syndrome,PNS)的關繫.方法 採用酶聯免疫吸附法(ELISA)檢測46例PNS患者及30例健康體檢者血清中TWEAK、HMGB-1及NF-κB的濃度,收集兩組的臨床資料,進行統計學分析.結果 PNS患者血清中TWEAK、HMGB-1及NF-κB的錶達水平均顯著高于健康對照組(P＜0.01),TWEAK、HMGB-1及NF-κB、CRP的錶達相互之間呈正相關(P＜0.01),併與尿蛋白、總膽固醇、甘油三酯、低密度脂蛋白、CRP之間呈正相關(P＜0.01),與血清白蛋白之間呈負相關(P＜0.01).結論 TWEAK、HMGB-1、NF-κB在PNS中錶達水平上調,且相互呈正相關.推測血清TWEAK、HMGB-1可能通過激活NF-κB信號通路在PNS髮病中髮揮瞭作用.
목적 탐토혈청중종류배사양조망미약유도제(TNF-like weak inducer of apoptosis,TWEAK)、고천이솔족단백-1(high mobility group box-1,HMGB-1)급핵인자-κB(nuclear factor-kappa B,NF-κB)여원발성신병종합정(primary nephritic syndrome,PNS)적관계.방법 채용매련면역흡부법(ELISA)검측46례PNS환자급30례건강체검자혈청중TWEAK、HMGB-1급NF-κB적농도,수집량조적림상자료,진행통계학분석.결과 PNS환자혈청중TWEAK、HMGB-1급NF-κB적표체수평균현저고우건강대조조(P＜0.01),TWEAK、HMGB-1급NF-κB、CRP적표체상호지간정정상관(P＜0.01),병여뇨단백、총담고순、감유삼지、저밀도지단백、CRP지간정정상관(P＜0.01),여혈청백단백지간정부상관(P＜0.01).결론 TWEAK、HMGB-1、NF-κB재PNS중표체수평상조,차상호정정상관.추측혈청TWEAK、HMGB-1가능통과격활NF-κB신호통로재PNS발병중발휘료작용.
Objectives To investigate the correlation among the concentration of TWEAK、HMGB-1 and NF-κB expressions of serum and primary nephrotic syndrome.Methods Serum TWEAK、HMGB-1and NF-κB levels were evaluated by enzyme-linked immunosorbent assay (ELISA) in 46 patients with primary nephrotic syndrome,coupled with 20 cases of healthy volunteers as normal control group.Relevant clinical data of the two groups were collected for statistical analysis.Results The expression levels of TWEAK 、HMGB-1、NF-κB were significantly higher in PNS patients than in normal control group,and these indicators showed a positive correlation.And they were positively correlated with urine protein、TG、CHOL、LDL、CRP,while were negatively correlated with ALB.Conclusions The expression levels of TWEAK、HMGB-1、NF-κB in nephrotic syndrome were increased,and they showed a positive correlation.We can speculate that TWEAK 、HMGB-1 possibly activates the NF -κB in the pathogenesis of nephrotic syndrome.
