CAJ | 학술논문

目的：探讨叉头框蛋白Q1（FOXQ1）和E-钙黏蛋白（E-cadherin）在食管鳞状细胞癌（ESCC）中的表达及临床意义。方法采用免疫组织化学法检测42例ESCC组织（ESCC组）及其癌旁正常食管鳞状上皮组织（正常组）中FOXQ1和E-cadherin的表达情况，分析其表达与患者临床病理特征及预后的关系。结果 ESCC组FOXQ1的阳性表达率高于正常组（64.29%vs 28.57%，χ2=5.384，P＜0.05），E-cadherin的阳性表达率低于正常组（52.38%vs 90.48%，χ2=7.691，P＜0.05）。FOXQ1的表达强度在不同TNM分期及不同淋巴结转移情况间的差异有统计学意义，E-cad?herin的表达强度在不同浸润深度、分化程度、TNM分期和淋巴结转移情况间的差异有统计学意义。ESCC组织中FOXQ1和 E-cadherin 的表达呈负相关（r =-0.412，P<0.05）。FOXQ1高表达者的5年生存率低于低表达者（18.52%vs 66.67%，χ2=9.737，P<0.05），E-cadherin高表达者的5年生存率高于低表达者（59.09%vs 10.00%，χ2=10.996，P<0.05）。COX比例风险回归模型分析结果显示，FOXQ1高表达、E-cadherin低表达、有淋巴结转移是影响ESCC患者预后的独立危险因素。结论 FOXQ1和E-cadherin在ESCC组织中的表达呈现较好的相关性，联合检测两者的表达对于ESCC患者的预后判断及指导治疗具有一定的临床价值。
목적：탐토차두광단백Q1（FOXQ1）화E-개점단백（E-cadherin）재식관린상세포암（ESCC）중적표체급림상의의。방법채용면역조직화학법검측42례ESCC조직（ESCC조）급기암방정상식관린상상피조직（정상조）중FOXQ1화E-cadherin적표체정황，분석기표체여환자림상병리특정급예후적관계。결과 ESCC조FOXQ1적양성표체솔고우정상조（64.29%vs 28.57%，χ2=5.384，P＜0.05），E-cadherin적양성표체솔저우정상조（52.38%vs 90.48%，χ2=7.691，P＜0.05）。FOXQ1적표체강도재불동TNM분기급불동림파결전이정황간적차이유통계학의의，E-cad?herin적표체강도재불동침윤심도、분화정도、TNM분기화림파결전이정황간적차이유통계학의의。ESCC조직중FOXQ1화 E-cadherin 적표체정부상관（r =-0.412，P<0.05）。FOXQ1고표체자적5년생존솔저우저표체자（18.52%vs 66.67%，χ2=9.737，P<0.05），E-cadherin고표체자적5년생존솔고우저표체자（59.09%vs 10.00%，χ2=10.996，P<0.05）。COX비례풍험회귀모형분석결과현시，FOXQ1고표체、E-cadherin저표체、유림파결전이시영향ESCC환자예후적독립위험인소。결론 FOXQ1화E-cadherin재ESCC조직중적표체정현교호적상관성，연합검측량자적표체대우ESCC환자적예후판단급지도치료구유일정적림상개치。
Objective To investigate the expression levels and clinical significance of (forkhead box Q1) FOXQ1 and E-cadherin in esophageal squamous cell carcinoma (ESCC). Methods Expression levels of FOXQ1 and E-cadherin were in ESCC tissues (ESCC group, n=42) and adjacent normal esophageal tissues (control group, n=42) were detected using im?munohistochemistry. Correlations of FOXQ1 and E-cadherin expressions with clinical pathological parameters and progno?sis were analyzed between two groups. Results The expression level of FOXQ1 was significantly higher in ESCC group than that in control group(64.29% vs 28.57%,χ2=5.384,P<0.05). The expression level of E-cadherin was significantly lower in ESCC group than that incontrol group(52.38%vs 90.48%,χ2=7.691,P<0.05). There were significant differences in FOXQ1 expressions between different TNM stages and whether lymph node metastasis is involved within ESCC group. There were significant differences in expression of E-cadherin between different tumor differentiation, depth of invasion, TNM stage and whether lymph node metastasis is involved within ESCC group. The expression of FOXQ1 was negatively cor?related with E-cadherin in ESCC (r=-0.412, P<0.05). The 5-year survival rates were significantly lower with high expres?sion of FOXQ1 or with low expression of FOXQ1(18.52%vs 66.67%,χ2=9.737,P<0.05). The 5-year survival rates were significantly higher with high expression of E-cadherinor low expression of E-cadherin(59.09%vs 10.00%,χ2=10.996,P<0.05). A multivariate Cox's proportional hazard regression analysis indicated that high FOXQ1 expression, low E-cadherin expression and lymph node metastasis were independent prognostic factors for ESCC. Conclusion The expression of FOXQ1 and E-cadherin showed a good correlation with ESCC. And examining expressions of both FOXQ1 and E-cadherin in ESCC may have practical values in estimating the prognosis of ESCC and directing future treatment .