CAJ | 학술논문

目的：探讨血清低密度脂蛋白胆固醇（LDL-C）水平对老年男性高血压性脑出血急性期血肿扩大有无预测作用。方法收集我院2012年6月—2014年5月发病6 h以内的老年男性高血压性脑出血患者108例，按发病时LDL-C水平分为LDL-C＜2.49 mmol/L组和LDL-C≥2.49 mmol/L组，对2组患者入院时的收缩压（SBP）、舒张压（DBP）、血糖水平、凝血酶原时间（PT）、部分活化凝血酶时间（APTT）、纤维蛋白原（FIB）、血小板计数、血肿体积进行对比分析，并于发病24 h复查头CT了解2组血肿扩大情况并进行比较。应用Logistic回归模型，寻找对脑出血血肿扩大有预测价值的危险因素。结果2组患者入院时SBP、DBP、血糖水平、PT、APTT、FIB、PLT、血肿体积比较差异无统计学意义；LDL-C＜2.49 mmol/L组的血肿扩大发生率高于LDL-C≥2.49 mmol/L组（34.21%vs 11.43%，P＜0.05）。Logistic多元回归分析显示，LDL-C＜2.49 mmol/L是血肿扩大的危险因素。结论老年男性急性期高血压性脑出血患者LDL-C＜2.49 mmol/L时提示血肿扩大风险较高，应及早采取相关治疗措施。
목적：탐토혈청저밀도지단백담고순（LDL-C）수평대노년남성고혈압성뇌출혈급성기혈종확대유무예측작용。방법수집아원2012년6월—2014년5월발병6 h이내적노년남성고혈압성뇌출혈환자108례，안발병시LDL-C수평분위LDL-C＜2.49 mmol/L조화LDL-C≥2.49 mmol/L조，대2조환자입원시적수축압（SBP）、서장압（DBP）、혈당수평、응혈매원시간（PT）、부분활화응혈매시간（APTT）、섬유단백원（FIB）、혈소판계수、혈종체적진행대비분석，병우발병24 h복사두CT료해2조혈종확대정황병진행비교。응용Logistic회귀모형，심조대뇌출혈혈종확대유예측개치적위험인소。결과2조환자입원시SBP、DBP、혈당수평、PT、APTT、FIB、PLT、혈종체적비교차이무통계학의의；LDL-C＜2.49 mmol/L조적혈종확대발생솔고우LDL-C≥2.49 mmol/L조（34.21%vs 11.43%，P＜0.05）。Logistic다원회귀분석현시，LDL-C＜2.49 mmol/L시혈종확대적위험인소。결론노년남성급성기고혈압성뇌출혈환자LDL-C＜2.49 mmol/L시제시혈종확대풍험교고，응급조채취상관치료조시。
Objective To investigate whether serum level of low-density lipoprotein cholesterol can predict the expan?sion of hemorrhage growth in elderly male patients with acute hypertensive intracerebral hemorrhage. Methods Patients (n=108) who visited our hospital with from June 2012 until May 2014 spontaneous hypertensive intracerebral hemorrhage with?in 6 hours of onset which is confirmed by initial computed tomography (CT) were sent to repeated CT within 24 hours of on?set. All selected patients were divided into the LDL-C≥2.49 mmol/L group and LDL-C<2.49 mmol/L group. Clinical data of these 2 groups were compared and the relationships of hematoma growth and its risk factors were analyzed. Results Baseline blood pressure, the level of blood glucose, PT, APTT, FIB, PLT and hemorrhage volume did not differ significantly between the LDL-C≥2.49 mmol/L group and LDL-C<2.49 mmol/L group. The ratio of hemorrhage growth in LDL-C<2.49 mmol/L group was significantly higher than that in LDL-C≥2.49 mmol/L group (34.21%vs 11.43%). Multiple logistic regres?sion analysis showed that LDL-C<2.49 mmol/L was the only risk factor contribute to hemorrhage growth. Conclusion Pa?tients with LDL-C<2.49 mmol/L in acute intracerebral hemorrhage are of high risk of hemorrhage growth so early attention and appropriate procedure are needed to prevent or slow its growth.