CAJ | 학술논문

目的：探讨PCSK9 rs11206510基因多态性与脂代谢及发生冠心病（CHD）风险的相关研究。方法选择在天津市胸科医院住院患者778例，分为CHD组502例和对照组276例。入院后检验三酰甘油(TG)、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白(Apo)A1、ApoB并检测入选人群的基因型TT、TC、CC。结果 CHD组TC基因型组LDL-C水平较TT基因型组高（P＜0.05）。CHD组和对照组均以TT基因型为主，2组基因型频率分布和等位基因频率分布差异均无统计学意义（P＞0.05）。被检总人群等位基因频率分别为 T 96.1%(1495/1556)，C 3.9%(61/1556)；基因型频率分别为TT 92.2%(717/778)，TC 7.8%(61/778)。多因素Logistic回归分析ApoA1、HDL-C是CHD的保护因素。结论 CHD组TC基因型与血清LDL-C的升高有相关性，而等位基因C与CHD的发病无明显相关性。
목적：탐토PCSK9 rs11206510기인다태성여지대사급발생관심병（CHD）풍험적상관연구。방법선택재천진시흉과의원주원환자778례，분위CHD조502례화대조조276례。입원후검험삼선감유(TG)、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）、재지단백(Apo)A1、ApoB병검측입선인군적기인형TT、TC、CC。결과 CHD조TC기인형조LDL-C수평교TT기인형조고（P＜0.05）。CHD조화대조조균이TT기인형위주，2조기인형빈솔분포화등위기인빈솔분포차이균무통계학의의（P＞0.05）。피검총인군등위기인빈솔분별위 T 96.1%(1495/1556)，C 3.9%(61/1556)；기인형빈솔분별위TT 92.2%(717/778)，TC 7.8%(61/778)。다인소Logistic회귀분석ApoA1、HDL-C시CHD적보호인소。결론 CHD조TC기인형여혈청LDL-C적승고유상관성，이등위기인C여CHD적발병무명현상관성。
Objective To investigate the relationship between PCSK9 gene polymorphism with lipid metabolism and CHD risk among population within Tianjin, China. Methods Patients from Tianjin Chest Hospital were selected (n=778) and divided into coronary heart disease (CHD) group (n=502) and control group (n=276). Immediately after admission, tri?glyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), apolipoprotein A (ApoA 1) and apolipo?protein B (ApoB) were tested and genotype TT,TC and CC were determined. Results In CHD group, LDL-C level is higher in TC genotype individuals than that in TT genotype individuals with statistical significance (P<0.05). CHD group and the control group were dominated by TT genotype with no statistical difference between their allele frequency distribution nor genotype frequency distribution(P>0.05). The total population allele frequencies were T 96.1%(1 495/1 556), C 3.9%(61/1 556);genotype frequencies were TT 92.2%(717/778), TC 7.8%(61/778). Multivariate Logistic regression analysis revealed that ApoA1 and HDL-C were inversely associated with coronary heart disease, therefore are protective factors for coronary heart disease. Conclusion The study found that TC genotype is correlated with serum LDL-C increase in group CHD, and the incidence of allele C showed no obvious connection with CHD.