CAJ | 학술논문

目的：检测 HSF1与 XAF1基因在子宫内膜组织中的表达，分析其与临床病理学特征的关系。方法采用免疫组织化学 S-P 法检测64例子宫内膜癌组织(EC 组)、33例正常子宫内膜组织(NE 组)中两者的表达情况，并观察其相关性。结果子宫内膜癌组织中 HSF1阳性表达率为76.6%，显著高于正常子宫内膜组织36.4%(P <0.05)；子宫内膜癌及正常子宫内膜组织 XAF1阳性率分别为31.2%和72.7%，差别具有统计学意义(P <0.05)；在 EC 组中 HSF1的阳性表达率在不同的组织学分级、肌层浸润及淋巴结转移间差异有统计学意义(P <0.05)；在 EC 组中 XAF1的阳性表达率在不同的组织学分级、肌层浸润、手术病理分期及淋巴结转移间差异有统计学意义(P <0.05)；子宫内膜癌组织中 HSF1与 XAF1表达水平呈负相关(P <0.05)。结论在子宫内膜癌组织中 HSF1的高表达可能通过抑制XAF1的表达致使细胞过度生长，抑制肿瘤细胞发生凋亡，导致肿瘤进一步发展。
목적：검측 HSF1여 XAF1기인재자궁내막조직중적표체，분석기여림상병이학특정적관계。방법채용면역조직화학 S-P 법검측64례자궁내막암조직(EC 조)、33례정상자궁내막조직(NE 조)중량자적표체정황，병관찰기상관성。결과자궁내막암조직중 HSF1양성표체솔위76.6%，현저고우정상자궁내막조직36.4%(P <0.05)；자궁내막암급정상자궁내막조직 XAF1양성솔분별위31.2%화72.7%，차별구유통계학의의(P <0.05)；재 EC 조중 HSF1적양성표체솔재불동적조직학분급、기층침윤급림파결전이간차이유통계학의의(P <0.05)；재 EC 조중 XAF1적양성표체솔재불동적조직학분급、기층침윤、수술병리분기급림파결전이간차이유통계학의의(P <0.05)；자궁내막암조직중 HSF1여 XAF1표체수평정부상관(P <0.05)。결론재자궁내막암조직중 HSF1적고표체가능통과억제XAF1적표체치사세포과도생장，억제종류세포발생조망，도치종류진일보발전。
ABSTRACT:Objective To test the expressions of heat shock transcription factor 1 (HSF1 )and XIAP-associated factor 1 (XAF1 )in different endometrial tissues,and analyze the association between their expressions and the clinicopathological features of this malignancy.Methods The expressions of HSF1 and XAF1 in 64 cases of endometria1 carcinoma (EC group)and 33 cases of normal endometrial tissues (NE group)were detected with immunohistochemistry S-P method.The correlation was observed.Results The positive expression rate of HSF1 was much higher in EC group than in NE group (76.6% vs .36.4%,P <0.05).The positive rate of XAF1 was 31.2% in EC group and 72.7% in NE group (P <0.05).The positive expressions of HSF1 and different subgroups of histological grade,myometrial invasion and lymph node metastasis were significantly different (P <0.05)in EC group.The positive expressions of XAF1 and different subgroups of histological grade,myometrial invasion,clinical stage and lymph node metastasis were significantly different (P < 0.05 )in EC group.There was a negative correlation between HSF1 and XAF1 in EC group (P <0.05).Conclusion In EC group,the high expression of HSF1 may inhibit the growth of XAF1 expression,cause excessive growth of cancer cells,reduce the apoptosis of cancer cells,and finally lead to the further development of tumors.