CAJ | 학술논문

麻醉药物的作用机理、对机体的影响以及相关病理毒理性研究及其依赖性问题一直受到人们的关注。MicroRNAs（miRNAs）作为细胞内不编码蛋白的短RNA，其与肿瘤发生、炎症反应等病理反应之间的关系是近年来研究的热点问题。研究发现，临床常用的麻醉药物对miRNA的表达也有影响，探索麻醉药物诱导miRNA基因表达的改变有助于加深对麻醉药物作用机制的理解。文中就目前已知miRNA与麻醉药物的相关性及其研究进展作一综述。
마취약물적작용궤리、대궤체적영향이급상관병리독이성연구급기의뢰성문제일직수도인문적관주。MicroRNAs（miRNAs）작위세포내불편마단백적단RNA，기여종류발생、염증반응등병리반응지간적관계시근년래연구적열점문제。연구발현，림상상용적마취약물대miRNA적표체야유영향，탐색마취약물유도miRNA기인표체적개변유조우가심대마취약물작용궤제적리해。문중취목전이지miRNA여마취약물적상관성급기연구진전작일종술。
It has long been concerned about the mechanism , pathology and toxicology of anaesthetic involving drug addiction and its influence on human body .In recent years , as a short non-coding RNA negatively regulating the genes in cells , MicroRNAs (miRNAs) may turn out to be a focus issue which is related to apoptosis , metabolism, inflammation, and tumorigenesis.This article illuminates the influence on gene expression introduced by common anaesthetics and the interaction between gene and its target site . Analyzing the potential medical applications of miRNA , this article reviews the correlation between miRNAs and anaesthetic to provide new evidences in this emerging field .