中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
2期
255-257
,共3页
瑞舒伐他汀%阿托伐他汀%冠心病%肝功能%肝损伤
瑞舒伐他汀%阿託伐他汀%冠心病%肝功能%肝損傷
서서벌타정%아탁벌타정%관심병%간공능%간손상
Rosuvastatin%Atorvastatin%Coronary heart disease%Liver function%Liver damage
目的：：评估阿托伐他汀与瑞舒伐他汀长期应用对冠心病患者血脂水平和肝功能的影响。方法：采用回顾性分析方法，选择我院住院冠心病患者200例，根据他汀类药物应用情况，分为阿托伐他汀组(102例)和瑞舒伐他汀组(98例)，比较两组患者应用他汀后1周、1个月、3个月、6个月和12个月的血脂和肝功能水平变化。结果：两组患者治疗后各时期的TC、LDL-C水平差异均无统计学意义(P>0.05)。两组患者治疗后AST和ALT较治疗前显著升高(P<0.05)，但两组间差异均无统计学意义(P>0.05)。结论：两种他汀降脂效果相似，但均可导致肝酶升高。
目的：：評估阿託伐他汀與瑞舒伐他汀長期應用對冠心病患者血脂水平和肝功能的影響。方法：採用迴顧性分析方法，選擇我院住院冠心病患者200例，根據他汀類藥物應用情況，分為阿託伐他汀組(102例)和瑞舒伐他汀組(98例)，比較兩組患者應用他汀後1週、1箇月、3箇月、6箇月和12箇月的血脂和肝功能水平變化。結果：兩組患者治療後各時期的TC、LDL-C水平差異均無統計學意義(P>0.05)。兩組患者治療後AST和ALT較治療前顯著升高(P<0.05)，但兩組間差異均無統計學意義(P>0.05)。結論：兩種他汀降脂效果相似，但均可導緻肝酶升高。
목적：：평고아탁벌타정여서서벌타정장기응용대관심병환자혈지수평화간공능적영향。방법：채용회고성분석방법，선택아원주원관심병환자200례，근거타정류약물응용정황，분위아탁벌타정조(102례)화서서벌타정조(98례)，비교량조환자응용타정후1주、1개월、3개월、6개월화12개월적혈지화간공능수평변화。결과：량조환자치료후각시기적TC、LDL-C수평차이균무통계학의의(P>0.05)。량조환자치료후AST화ALT교치료전현저승고(P<0.05)，단량조간차이균무통계학의의(P>0.05)。결론：량충타정강지효과상사，단균가도치간매승고。
Objective:To evaluate the influence of atorvastatin and rosuvastatin on the lipid level and liver function in the patients with coronary heart disease (CHD). Methods:The CHD patients in our hospital were selected from January 2011 to December 2012. According to statin types, the patients were divided into atorvastatin group (n=102) and rosuvastatin group (n=98), and the lipid level and liver function in the first week, and the first, third, 6th and 12th month after the statin treatment were evaluated. Results:TC and LDL-c levels of the two groups had no statistical differences in the same period (P>0. 05). AST and ALT levels were signifi-cantly increased after the statin treatment (P<0. 05), while no statistically significant difference was shown between the two groups (P>0. 05). Conclusion:Atorvastatin and rosuvastatin have the similar lipid-lowering effect, and both can increase liver enzymes.
