CAJ | 학술논문

目的：：建立离子色谱法测定头孢噻吩钠中的钠离子含量,并考察其成盐状态。方法：分析柱为TSKgelSuper IC-CR阳离子柱(150 mm ×4.6 mm,3.0μm),流动相为2.2 mmol·L-1甲烷磺酸与1 mmol·L-118-冠-6-醚的混合溶液,流速为0.8 ml ·min-1,柱温为40℃,进样量为20μl。检测器为电导检测器。结果：钠离子在3.0~60.0μg·ml-1范围内线性关系良好(r=0.9999),平均回收率为99.8%(RSD=0.8%, n=9)。样品中钠离子与头孢噻吩酸的摩尔数比在0.97~1.03之间。结论：所建立的离子色谱法专属性强,精密度好,准确度高,可用于头孢噻吩钠中钠离子定量测定。8批样品的成盐状态良好。
목적：：건립리자색보법측정두포새분납중적납리자함량,병고찰기성염상태。방법：분석주위TSKgelSuper IC-CR양리자주(150 mm ×4.6 mm,3.0μm),류동상위2.2 mmol·L-1갑완광산여1 mmol·L-118-관-6-미적혼합용액,류속위0.8 ml ·min-1,주온위40℃,진양량위20μl。검측기위전도검측기。결과：납리자재3.0~60.0μg·ml-1범위내선성관계량호(r=0.9999),평균회수솔위99.8%(RSD=0.8%, n=9)。양품중납리자여두포새분산적마이수비재0.97~1.03지간。결론：소건립적리자색보법전속성강,정밀도호,준학도고,가용우두포새분납중납리자정량측정。8비양품적성염상태량호。
Objective:To establish a method for the determination of sodion in cefalotin sodium by ion chromatography and investi-gate the salt-forming rate of the products. Methods: A TSKgelSuper IC-CR cation exchange column (150 mm × 4. 6 mm, 3. 0 μm) was used. The mobile phase was the mixture of 2. 2 mmol·L-1 methanesulfonic acid and 1 mmol·L-1 18-crown-6-ether with the flow rate of 0. 8 ml·min-1 . The column temperature was 40℃ and the injection volume was 20μl. The detector was an electric conductiv-ity detector. Results:The linear correlation of sodion was good within the range of 3. 0-60. 0μg·ml-1(r=0. 999 9). The average re-covery was 99. 8%(RSD=0. 8%, n=9). The mole number ratio of sodion to cefalotin was within the range of 0. 97-1. 03. Conclu-sion:The method is specific, precise and accurate, and can be used in the determination of sodion in cefalotin sodium. The salt-form-ing rate of the 8 batches of samples is promising.