CAJ | 학술논문

目的：：探讨复方桑钩颗粒对高血脂大鼠纤维蛋白原( Fib)及抗凝血酶Ⅲ( AT-Ⅲ)、组织型纤溶原激活物( t-PA)、组织型纤溶原激活物抑制剂-1(PAI-1)水平的影响。方法：采用高脂饲料喂养建立高血脂症病理模型。 SD雄性大鼠60只随机分为正常对照组、模型空白组、复方桑钩颗粒高剂量组、低剂量组和氟伐他汀钠组,每组12只。给药4周后采血测定各组大鼠血脂水平、Fib含量、AT-Ⅲ、t-PA、PAI-1及t-PA/ PAI-1比值。结果：与正常对照组比较,模型空白组大鼠血脂总胆固醇( TC)、低密度脂蛋白胆固醇(LDL-C)明显升高(P<0.01),高密度脂蛋白胆固醇(HDL-C)明显降低(P<0.01)。模型空白组Fib含量、PAI-1值较正常对照组明显增加；AT-Ⅲ活度、t-PA值、t-PA/ PAI-1比值则较正常对照组明显降低(P<0.01)。高剂量组的TC、LDL-C、PAI-1、Fib与模型空白组比较,水平明显降低(P<0.01或0.05),HDL-C、t-PA、t-PA/ PAI-1、AT-Ⅲ则明显升高(P<0.01或0.05)；低剂量组大鼠的TC、LDL-C、PAI-1水平明显降低,t-PA/ PAI-1显著升高(P<0.01),其他无明显影响。氟伐他汀钠组除AT-Ⅲ水平无显著影响(P>0.05)外,其余各指标的变化与高剂量组相当。结论：复方桑钩颗粒在降低高血脂模型大鼠血脂的同时,能改善高血脂大鼠的高凝状态、提高抗凝和纤溶能力,尤其是高剂量组,效果与氟伐他汀钠相当,在抗凝方面甚至优于氟伐他汀钠。
목적：：탐토복방상구과립대고혈지대서섬유단백원( Fib)급항응혈매Ⅲ( AT-Ⅲ)、조직형섬용원격활물( t-PA)、조직형섬용원격활물억제제-1(PAI-1)수평적영향。방법：채용고지사료위양건립고혈지증병리모형。 SD웅성대서60지수궤분위정상대조조、모형공백조、복방상구과립고제량조、저제량조화불벌타정납조,매조12지。급약4주후채혈측정각조대서혈지수평、Fib함량、AT-Ⅲ、t-PA、PAI-1급t-PA/ PAI-1비치。결과：여정상대조조비교,모형공백조대서혈지총담고순( TC)、저밀도지단백담고순(LDL-C)명현승고(P<0.01),고밀도지단백담고순(HDL-C)명현강저(P<0.01)。모형공백조Fib함량、PAI-1치교정상대조조명현증가；AT-Ⅲ활도、t-PA치、t-PA/ PAI-1비치칙교정상대조조명현강저(P<0.01)。고제량조적TC、LDL-C、PAI-1、Fib여모형공백조비교,수평명현강저(P<0.01혹0.05),HDL-C、t-PA、t-PA/ PAI-1、AT-Ⅲ칙명현승고(P<0.01혹0.05)；저제량조대서적TC、LDL-C、PAI-1수평명현강저,t-PA/ PAI-1현저승고(P<0.01),기타무명현영향。불벌타정납조제AT-Ⅲ수평무현저영향(P>0.05)외,기여각지표적변화여고제량조상당。결론：복방상구과립재강저고혈지모형대서혈지적동시,능개선고혈지대서적고응상태、제고항응화섬용능력,우기시고제량조,효과여불벌타정납상당,재항응방면심지우우불벌타정납。
Objective:To investigate the effect of compound Sanggou granules on the activity of Fib, AT-Ⅲ, t-PA, PAI-1 and t-PA/ PAI-1 in hyperlipidemic rats. Methods: The hyperlipidemic rat model was established by feeding high fat diet to SD male rats. Sixty healthy SD rats were randomly divided into five groups: the normal diet control group, high fat control group, high dose drug group, low dose drug group and fluvastatin sodium group. Four weeks after the administration, the blood samples were withdrawn for the determination of the levels of blood lipid, Fib, A-Ⅲ, t-PA, PAI-1 and t-PA/ PAI-1. Results:Compared with those of the normal diet control group, the levels of TC, LDL-C, Fib and PAI-1 were increased and the levels of HDL-C, t-PA , AT-Ⅲand t-PA/ PAI-1 were decreased significantly (P<0. 01) in the high fat control group. Compared with those of the high fat control group, the levels of TC, LDL-C, PAI-1 and Fib were decreased(P<0. 01 or P<0. 05),and the levels of HDL-C, t-PA AT-Ⅲ and t-PA/PAI-1 were in-creased significantly in the high dose drug group (P<0. 05 or P<0. 01). The similar effects were shown in the fluvastatin sodium group with the stability of AT-Ⅲ. The levels of TC, LDL-C and PAI-1 were decreased and the levels of t-PA/PAI-1 were increased no-tably in the low dose drug group. Conclusion: Compound Sanggou granules exhibit hypolipidemic effect in hyperlipidemic rats, and can improve hypercoagulability and enhance anticoagulation and fibrinolytic activity in hyperlipidemic rats. Furthermore, compound Sanggou granules at high dose show the same effect as fluvastatin sodium, even in anticoagulation, the granules are superior to fluvasta-tin sodium.