中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
2期
271-272,279
,共3页
氟伐他汀%早期糖尿病肾病%高敏C-反应蛋白%肿瘤坏死因子-α%尿微量白蛋白排泄率
氟伐他汀%早期糖尿病腎病%高敏C-反應蛋白%腫瘤壞死因子-α%尿微量白蛋白排洩率
불벌타정%조기당뇨병신병%고민C-반응단백%종류배사인자-α%뇨미량백단백배설솔
Fluvastatin%Diabetic nephropathy%Hs-CRP%TNF-α%UAER
目的：：观察氟伐他汀对早期糖尿病肾病患者高敏C-反应蛋白( hs-CRP)、肿瘤坏死因子-α( TNF-α)、尿微量白蛋白排泄率( UAER)和血清肌酐( Cr)的影响。方法：69例早期糖尿病肾病患者随机分为观察组34例(低蛋白饮食+氟伐他汀)和对照组35例(低蛋白饮食),两组患者疗程均为8周,分别于治疗前后检测hs-CRP、TNF-α、UAER、ALT 、Cr水平,并与同期另设的正常组65例的上述指标水平进行比较。结果：与治疗前相比,对照组治疗后UAER水平明显下降(P<0.05)； hs-CRP 、TNF-α水平下降不明显(P>0.05)；观察组治疗后UAER 、hs-CRP 、TNF-α水平均明显下降(P<0.05或0.01),且明显低于低于对照组同期(P<0.05或0.01)。两组治疗前后ALT、Cr变化差异无统计学意义(P>0.05),但治疗8周时观察组Cr明显低于对照组(P<0.05)。观察组、对照组在治疗前后UAER、hs-CRP、TNF-α均明显高于正常组(P<0.05)；ALT、Cr与正常组比较差异无统计学意义(P>0.05)。结论：UAER、hs-CRP、TNF-α与糖尿病肾病密切相关,氟伐他汀与低蛋白饮食联合治疗早期DN,可显著抑制炎症因子hs-CRP 、TNF-α,降低UAER。
目的：：觀察氟伐他汀對早期糖尿病腎病患者高敏C-反應蛋白( hs-CRP)、腫瘤壞死因子-α( TNF-α)、尿微量白蛋白排洩率( UAER)和血清肌酐( Cr)的影響。方法：69例早期糖尿病腎病患者隨機分為觀察組34例(低蛋白飲食+氟伐他汀)和對照組35例(低蛋白飲食),兩組患者療程均為8週,分彆于治療前後檢測hs-CRP、TNF-α、UAER、ALT 、Cr水平,併與同期另設的正常組65例的上述指標水平進行比較。結果：與治療前相比,對照組治療後UAER水平明顯下降(P<0.05)； hs-CRP 、TNF-α水平下降不明顯(P>0.05)；觀察組治療後UAER 、hs-CRP 、TNF-α水平均明顯下降(P<0.05或0.01),且明顯低于低于對照組同期(P<0.05或0.01)。兩組治療前後ALT、Cr變化差異無統計學意義(P>0.05),但治療8週時觀察組Cr明顯低于對照組(P<0.05)。觀察組、對照組在治療前後UAER、hs-CRP、TNF-α均明顯高于正常組(P<0.05)；ALT、Cr與正常組比較差異無統計學意義(P>0.05)。結論：UAER、hs-CRP、TNF-α與糖尿病腎病密切相關,氟伐他汀與低蛋白飲食聯閤治療早期DN,可顯著抑製炎癥因子hs-CRP 、TNF-α,降低UAER。
목적：：관찰불벌타정대조기당뇨병신병환자고민C-반응단백( hs-CRP)、종류배사인자-α( TNF-α)、뇨미량백단백배설솔( UAER)화혈청기항( Cr)적영향。방법：69례조기당뇨병신병환자수궤분위관찰조34례(저단백음식+불벌타정)화대조조35례(저단백음식),량조환자료정균위8주,분별우치료전후검측hs-CRP、TNF-α、UAER、ALT 、Cr수평,병여동기령설적정상조65례적상술지표수평진행비교。결과：여치료전상비,대조조치료후UAER수평명현하강(P<0.05)； hs-CRP 、TNF-α수평하강불명현(P>0.05)；관찰조치료후UAER 、hs-CRP 、TNF-α수평균명현하강(P<0.05혹0.01),차명현저우저우대조조동기(P<0.05혹0.01)。량조치료전후ALT、Cr변화차이무통계학의의(P>0.05),단치료8주시관찰조Cr명현저우대조조(P<0.05)。관찰조、대조조재치료전후UAER、hs-CRP、TNF-α균명현고우정상조(P<0.05)；ALT、Cr여정상조비교차이무통계학의의(P>0.05)。결론：UAER、hs-CRP、TNF-α여당뇨병신병밀절상관,불벌타정여저단백음식연합치료조기DN,가현저억제염증인자hs-CRP 、TNF-α,강저UAER。
Objective:To investigate the effects of fluvastatin on high-sensitivity c-reactive protein( hs-CRP) , tumor necrosis fac-tor-α(TNF-α), urine albumer excretion rate (UAER)and serum creatinine (Cr) in the patients with early diabetic nephropathy. Methods:Totally 69 patients with early diabetic nephropathy were randomly divided into the observation group with 34 cases and the control group with 35 cases. The observation group was treated by low-protein diet plus fluvastatin, and the control group was treated by low-protein diet only. The course of treatment was 8 weeks. Totally 65 nondiabetic persons were selected as the normal group, and the levels of TNF-α, hs-CRP, UAER, ALT and Cr were detected before and after the treatment. Results:The levels of TNF-α, hs-CRP and UAER in the observation group and the control group were significantly higher than those in the normal group(P<0. 05);the lev-els of ALT and Cr showed no significant differences (P>0. 05). Compared with that before the treatment, the level of UAER was de-creased significantly in the control group after the treatment (P<0. 05), and the levels of TNF-α and hs-CRP showed no significant differences after the treatment (P>0. 05). In the observation group, the levels of TNF-α, hs-CRP and UAER were all decreased sig-nificantly after the treatment (P<0. 05). Conclusion:UAER, hs-CRP and TNF-α are closely connected with diabetic nephropathy. Fluvastatin can decrease the levels of TNF-α, hs-CRP and UAER. Low-protein diet plus fluvastatin is effective and safe in the treat-ment of early diabetic nephropathy, and the efficacy is superior to that of low-protein diet only.
