CAJ | 학술논문

目的：评估抗菌药物使用综合干预效果，为规范医院抗菌药物合理应用提供参考。方法：干预措施：采取药学干预和行政干预相结合的方式，对医院抗菌药物使用进行综合干预。效果评估：分别调取我院2012年6月-2013年5月（干预前）、2013年6月-2014年5月（干预后）使用过抗菌药物的病区及门诊病历作为对照组和干预组，从综合干预前后抗菌药物的使用率、使用强度（DDD, Daily Defined Dose）以及特殊使用级抗菌药物的送检率、抗菌药物联用情况等几个方面评估综合干预效果。结果：干预组抗菌药物的平均使用率、平均使用强度分别为59.18%和35.19DDD，低于对照组的71.39%和45.64 DDD；特殊使用级抗菌药物的送检率由26.65%上升至81.58%；抗菌药物联合用药情况更趋于合理。结论：采取综合干预措施可以降低门诊和病区病例抗菌药物的使用率、使用强度；提高特殊使用级抗菌药物的送检率，抗菌药物联用更趋于合理。
목적：평고항균약물사용종합간예효과，위규범의원항균약물합리응용제공삼고。방법：간예조시：채취약학간예화행정간예상결합적방식，대의원항균약물사용진행종합간예。효과평고：분별조취아원2012년6월-2013년5월（간예전）、2013년6월-2014년5월（간예후）사용과항균약물적병구급문진병력작위대조조화간예조，종종합간예전후항균약물적사용솔、사용강도（DDD, Daily Defined Dose）이급특수사용급항균약물적송검솔、항균약물련용정황등궤개방면평고종합간예효과。결과：간예조항균약물적평균사용솔、평균사용강도분별위59.18%화35.19DDD，저우대조조적71.39%화45.64 DDD；특수사용급항균약물적송검솔유26.65%상승지81.58%；항균약물연합용약정황경추우합리。결론：채취종합간예조시가이강저문진화병구병례항균약물적사용솔、사용강도；제고특수사용급항균약물적송검솔，항균약물련용경추우합리。
Objective: To investigate and analyze comprehensive intervention for the hospital antimicrobial usage and to promote and regulate the rational use of antibiotics in the hospital.Methods: Comprehensive intervention for antimicrobial drug usage was performed which combined pharmaceutical and administrative interventions. Medical records from wards where antimicrobial agents were used and clinics from June 2012 to May 2013 (before intervention) and from June 2013 to May 2014 (after intervention) were collected and assigned as the control group and the intervention group respectively. The comprehensive intervention effects were evaluated from aspects such as usage rate, usage intensity before and after the intervention, delivery rate of antimicrobial drugs for special use and combined use of antimicrobial drugs.Results: The average usage rate and average intensity of antimicrobial drugs were 59.18%and 35.19 DDD respectively in the intervention group while they were lower than 71.39%, 45.64 DDD in the control group. The delivery rate of antimicrobial agents for special use increased from 26.65% to 81.58%. Combination therapy of antimicrobial drugs tended to be more reasonable.Conclusion: Comprehensive intervention can reduce the antimicrobial usage rate and intensity in outpatient clinics and wards and improve the delivery rate of antimicrobial drugs for special use, and the antimicrobial combination therapy tends to be more reasonable.