中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
2期
348-349
,共2页
正交试验%复方乳酸钠注射液%澄明度
正交試驗%複方乳痠鈉註射液%澄明度
정교시험%복방유산납주사액%징명도
Orthogonal test%Compound sodium lactate injections%Clarity
目的：：优选提高复方乳酸钠注射液澄明度的最佳工艺。方法：采用正交试验法,选择可能影响药液澄明度的4个因素：浓溶液脱炭温度(A),浓溶液pH(B),浓溶液脱炭时间(C),注射液灌装温度(D),每个因素取3个水平,以复方乳酸钠注射液澄明度合格率为指标,优选最佳工艺条件。结果：最佳工艺条件为浓溶液脱炭温度80℃,浓溶液pH 6.5,浓溶液脱炭时间20 min,注射液灌装温度50℃。结论：该优选工艺能提高复方乳酸钠注射液的澄明度。
目的：：優選提高複方乳痠鈉註射液澄明度的最佳工藝。方法：採用正交試驗法,選擇可能影響藥液澄明度的4箇因素：濃溶液脫炭溫度(A),濃溶液pH(B),濃溶液脫炭時間(C),註射液灌裝溫度(D),每箇因素取3箇水平,以複方乳痠鈉註射液澄明度閤格率為指標,優選最佳工藝條件。結果：最佳工藝條件為濃溶液脫炭溫度80℃,濃溶液pH 6.5,濃溶液脫炭時間20 min,註射液灌裝溫度50℃。結論：該優選工藝能提高複方乳痠鈉註射液的澄明度。
목적：：우선제고복방유산납주사액징명도적최가공예。방법：채용정교시험법,선택가능영향약액징명도적4개인소：농용액탈탄온도(A),농용액pH(B),농용액탈탄시간(C),주사액관장온도(D),매개인소취3개수평,이복방유산납주사액징명도합격솔위지표,우선최가공예조건。결과：최가공예조건위농용액탈탄온도80℃,농용액pH 6.5,농용액탈탄시간20 min,주사액관장온도50℃。결론：해우선공예능제고복방유산납주사액적징명도。
Objective:To optimize the preparation technology of compound sodium lactate injections for the improvement of clari-ty. Methods:The orthogonal test was adopted to screen the best preparation conditions using four influencing factors including the de-carburization temperature of the concentrated solution (A), pH value of the concentrated solution (B), decarburization time of the concentrated solution ( C) and the filling temperature of the injections ( D) with 3 levels for each, and the clarity of the injections as the index. Results:The best preparation conditions were as follows:the decarburization temperature was 60℃, pH value of the con-centrated solution was 6. 5, the decarburization time was 20minute and the filling temperature was 50℃. Conclusion: The optimal process can improve the clarity of compound sodium lactate injections.
