CAJ | 학술논문

目的：探讨甲状腺疾病患者血浆和乳汁中游离三碘甲酰原氨酸( FT3),游离甲状腺素(FT4),促甲状腺激素(TSH)相互之间的关系。方法收集女性甲亢(Graves 病)患者,女性正常人(NC)和女性桥本甲状腺功能减退(HT 或甲减)患者共102例,每例患者和正常人均留取血浆和乳汁,测定 FT3、FT4、TSH 含量,并选取了甲亢和甲减患者之婴儿各11例,分别进行了哺乳和停止哺乳2个月后血液甲状腺功能 FT3、FT4、TSH 含量测定。结果(1)3组乳汁中 FT3和 FT4含量有差异[(1.48±0.81)、(7.79±3.56)和(0.77±0.42)pg/ ml；(2.94±1.43)、(14.78±7.40)和(1.51±0.40)pg/ ml,均 P<0.05],乳汁中 TSH含量在甲亢组和正常人组间差异无统计学意义(P>0.05)。(2)甲亢组乳汁和血浆中 FT3比值与正常人组和甲减组间有差异(0.42±0.04对0.35±0.03、0.36±0.03,P<0.05),FT4和 TSH 在乳汁和血浆中比值无差异(均 P>0.05)。(3)甲亢和甲减患者之婴儿,在哺乳时期和停止哺乳2个月后,血液甲状腺功能 FT3、FT4和 TSH 含量有差异[(5.06±1.76)对(6.51±2.23)pg/ ml,(17.39±2.78)对(19.87± 3.26)pg/ ml,(1.34±1.33)对(0.74±0.78)mIU/ L；(1.43±0.74)对(1.83±0.91)pg/ ml,(4.28±1.55)对(5.00±1.75)pg/ ml,(6.48±2.70)对(5.49±2.39)mIU/ L；均 P<0.05]。(4)各组别 FT3、FT4血浆中浓度含量与乳汁中浓度含量呈正相关(均 P<0.05),TSH 在甲减组呈正相关(P<0.05)。结论血浆和乳汁中 FT3、FT4、TSH 含量存在相关性。
목적：탐토갑상선질병환자혈장화유즙중유리삼전갑선원안산( FT3),유리갑상선소(FT4),촉갑상선격소(TSH)상호지간적관계。방법수집녀성갑항(Graves 병)환자,녀성정상인(NC)화녀성교본갑상선공능감퇴(HT 혹갑감)환자공102례,매례환자화정상인균류취혈장화유즙,측정 FT3、FT4、TSH 함량,병선취료갑항화갑감환자지영인각11례,분별진행료포유화정지포유2개월후혈액갑상선공능 FT3、FT4、TSH 함량측정。결과(1)3조유즙중 FT3화 FT4함량유차이[(1.48±0.81)、(7.79±3.56)화(0.77±0.42)pg/ ml；(2.94±1.43)、(14.78±7.40)화(1.51±0.40)pg/ ml,균 P<0.05],유즙중 TSH함량재갑항조화정상인조간차이무통계학의의(P>0.05)。(2)갑항조유즙화혈장중 FT3비치여정상인조화갑감조간유차이(0.42±0.04대0.35±0.03、0.36±0.03,P<0.05),FT4화 TSH 재유즙화혈장중비치무차이(균 P>0.05)。(3)갑항화갑감환자지영인,재포유시기화정지포유2개월후,혈액갑상선공능 FT3、FT4화 TSH 함량유차이[(5.06±1.76)대(6.51±2.23)pg/ ml,(17.39±2.78)대(19.87± 3.26)pg/ ml,(1.34±1.33)대(0.74±0.78)mIU/ L；(1.43±0.74)대(1.83±0.91)pg/ ml,(4.28±1.55)대(5.00±1.75)pg/ ml,(6.48±2.70)대(5.49±2.39)mIU/ L；균 P<0.05]。(4)각조별 FT3、FT4혈장중농도함량여유즙중농도함량정정상관(균 P<0.05),TSH 재갑감조정정상관(P<0.05)。결론혈장화유즙중 FT3、FT4、TSH 함량존재상관성。
Objective To investigate the relationships among free triiodothyronine( FT3 ), free thyroxine (FT4 ), and thyroid-stimulating hormone( TSH) in both plasma and breast milk of patients with thyroid diseases. Methods A total of 102 female subjects with hyperthyroidism(GD), normal thyroid function(NC), and Hashimoto′s hypothyroidism(HT or hypothyroidism)were enrolled. Their plasma and breast milk were collected for measurement of FT3 and FT4 , and TSH. Meanwhile, 11 infants of patients with hyperthyroidism and another 11 infants of patients with hypothyroidism were selected, blood FT3 , FT4 , and TSH content were determined during lactating period and 2 months after lactation. Results (1) FT3 and FT4 contents in breast milk among 3 groups were different[(1. 48 ± 0. 81), (7. 79 ± 3. 56), and (0. 77 ± 0. 42)pg/ ml; (2. 94 ± 1. 43), (14. 78 ± 7. 40), and (1. 51 ± 0. 40)pg/ ml, P<0. 05], TSH in breast milk was similar between hyperthyroidism and normal groups(P>0. 05). (2) FT3 ratio of breast milk to plasma of the hyperthyroidism group was different to other 2 groups(0. 42 ± 0. 04 vs 0. 35 ± 0. 03, 0. 36 ± 0. 03, P<0. 05), but no difference existed in FT4 and TSH among 3 groups(both P>0. 05). (3)Blood FT3 , FT4 , and TSH contents from infants of patients with hyperthyroidism and hypothyroidism were different, both during lactating period and 2 months after lactation[(5. 06 ± 1. 76)vs (6. 51 ± 2. 23)pg/ ml, (17. 39 ± 2. 78)vs (19. 87 ± 3. 26)pg/ ml, (1. 34 ± 1. 33)vs (0. 74 ± 0. 78)mIU/ L; (1. 43 ± 0. 74)vs (1. 83 ± 0. 91)pg/ ml, (4. 28 ± 1. 55)vs (5. 00 ± 1. 75)pg/ ml, (6. 48 ± 2. 70) vs (5. 49 ± 2. 39) mIU/ L; all P<0. 05]. (4) FT3 and FT4 contents were positively correlated in plasma and breast milk(all P<0. 05), while TSH contents were positively correlated only in hypothyroidism group(P<0. 05). Conclusion FT3 , FT4 , and TSH in blood and breast milk are correlated.