CAJ | 학술논문

目的：观察葛根芩连汤合异功散加味治疗溃疡性结肠炎大肠湿热证的临床疗效，并评价其安全性。方法：68例溃疡性结肠炎大肠湿热证患者随机分为治疗组34例，对照组34例，治疗组给予葛根芩连汤合异功散加味治疗，1剂/d，对照组给予美沙拉嗪肠溶片，1g/d，口服治疗。疗程为4周。疗程结束后比较两组症状积分、肠镜及总有效率等指标，并监测用药安全性。结果：4周后治疗组的总有效率91.7%，高于对照组69.3%（P<0.01）。治疗后治疗组脓血便、症状总积分的改善优于对照组（P<0.05）。结论：葛根芩连汤合异功散加味方治疗溃疡性结肠炎大肠湿热证临床疗效确切，且具有良好的安全性，无明显不良反应，可以临床推广使用。
목적：관찰갈근금련탕합이공산가미치료궤양성결장염대장습열증적림상료효，병평개기안전성。방법：68례궤양성결장염대장습열증환자수궤분위치료조34례，대조조34례，치료조급여갈근금련탕합이공산가미치료，1제/d，대조조급여미사랍진장용편，1g/d，구복치료。료정위4주。료정결속후비교량조증상적분、장경급총유효솔등지표，병감측용약안전성。결과：4주후치료조적총유효솔91.7%，고우대조조69.3%（P<0.01）。치료후치료조농혈편、증상총적분적개선우우대조조（P<0.05）。결론：갈근금련탕합이공산가미방치료궤양성결장염대장습열증림상료효학절，차구유량호적안전성，무명현불량반응，가이림상추엄사용。
Objective: To observe clinical efficacy of the Gegen Qinlian decoction plus Yigong San on Dachang Shire type of ulcerative colitis. Methods: 68 cases were randomly divided into two groups, 34 cases for each. The treatment group was given the Gegen Qinlian decoction and Yigong San, and the control group was treated with mesalazin enteric-coated tablets, 4 weeks as 1 course. The index of symptom scores, enteroscopy and total efficacy in two groups were compared after treatment; safety of drugs was tested. Results: After 4 weeks, the total efficacy in treatment group (91.7%) was higher than that (69.3%) in the control group (P<0.01). After treatment, the improvement of bloody purulent stool and symptom scores in the treatment group was better than that in the control group (P<0.05). Conclusion: The Gegen Qinlian decoction plus Yigong San is an effective and safe method, with no adverse reactions, and is worthy of promotion.