CAJ | 학술논문

目的：观察自体骨髓干细胞移植联合血塞通注射液治疗糖尿病周围神经病变的疗效。方法将42例糖尿病周围神经病变的患者随机分为2组，治疗组21例(28例患肢)，对照组21例(28例患肢)。治疗组与对照组均进行自体骨髓干细胞移植手术，术后治疗组在常规治疗的基础上，予血塞通注射液静脉静注，对照组仅予常规术后治疗。观察2组术后2周、6个月的临床疗效，麻木评分，各阶段神经传导情况。结果术后2周、术后6个月治疗组临床疗效均优于对照组(P<0.05)。2组麻木评分术后2周、术后6个月较本组术前均有所减低，差异有统计学意义( P <0.05)，术后2周、术后6个月治疗组与对照组比较，患肢麻木评分均低于对照组，差异有统计学意义(P<0.05)。2组胫神经传导速度术后2周、术后6个月较本组术前均有所提高，差异有统计学意义(P<0.05)，术后2周、术后6个月治疗组提高值均较对照组提高值增加明显，差异有统计学意义(P<0.05)。2组腓总神经传导速度术后2周、术后6个月较本组术前均有所提高，差异有统计学意义(P<0.05)，术后2周、术后6个月治疗组提高值均较对照组提高值增加明显，差异有统计学意义(P<0.05)。2组腓肠神经传导速度术后2周、术后6个月较本组术前均有所提高，差异有统计学意义(P<0.05)，术后2周、术后6个月治疗组提高值均较对照组提高值增加明显，差异有统计学意义(P<0.05)。结论自体骨髓干细胞移植联合血塞通注射液治疗糖尿病周围神经病变具有较好的疗效。
목적：관찰자체골수간세포이식연합혈새통주사액치료당뇨병주위신경병변적료효。방법장42례당뇨병주위신경병변적환자수궤분위2조，치료조21례(28례환지)，대조조21례(28례환지)。치료조여대조조균진행자체골수간세포이식수술，술후치료조재상규치료적기출상，여혈새통주사액정맥정주，대조조부여상규술후치료。관찰2조술후2주、6개월적림상료효，마목평분，각계단신경전도정황。결과술후2주、술후6개월치료조림상료효균우우대조조(P<0.05)。2조마목평분술후2주、술후6개월교본조술전균유소감저，차이유통계학의의( P <0.05)，술후2주、술후6개월치료조여대조조비교，환지마목평분균저우대조조，차이유통계학의의(P<0.05)。2조경신경전도속도술후2주、술후6개월교본조술전균유소제고，차이유통계학의의(P<0.05)，술후2주、술후6개월치료조제고치균교대조조제고치증가명현，차이유통계학의의(P<0.05)。2조비총신경전도속도술후2주、술후6개월교본조술전균유소제고，차이유통계학의의(P<0.05)，술후2주、술후6개월치료조제고치균교대조조제고치증가명현，차이유통계학의의(P<0.05)。2조비장신경전도속도술후2주、술후6개월교본조술전균유소제고，차이유통계학의의(P<0.05)，술후2주、술후6개월치료조제고치균교대조조제고치증가명현，차이유통계학의의(P<0.05)。결론자체골수간세포이식연합혈새통주사액치료당뇨병주위신경병변구유교호적료효。
Objective To observe the curative effect of combination treatment with autologus bone marrow stem cell transplantation and Xuesaitong in treating diabetic peripheral neuropathy. Methods 42 patients with diabetic peripheral neuropathy were randomly divided into 2 groups, the treatment group ( n=21, including 28 sick limbs) and the control group(n=21, including 28 sick limbs). Both groups were treated with autogolus bone marrow stem cell transplantation, meanwhile, Xuesaitong injection was given to the treatment group. The curative effect, numb scores and neurotransmission at 2 week and 6 month after surgery were recorded. Results The curative effect of treatment group was superior to the control group at 2 week and 6 month after surgery ( P<0 . 05 ) . Numb scores before and after surgery of the two groups decreased significantly at 2 week and 6 month after surgery(P<0. 05). Compared to the control group, numb scores of the treatment group decreased significantly at 2 week and 6 month after surgery ( P <0 . 05 ) . The tibial nerve conduction velocity before and after surgery of both groups increased significantly at 2 week and 6 month after surgery (P<0. 05). Compared to the control group, the tibial nerve conduction velocity of treatment group increased significantly at 2 week and 6 month after surgery ( P <0 . 05 ) . The common peroneal nerve conduction velocity before and after surgery of both groups increased significantly at 2 week and 6 month after surgery ( P<0 . 05 ) . Compared to the control group, the common peroneal nerve conduction velocity of treatment group increased significantly at 2 week and 6 month after surgery ( P<0 . 05 ) . The sural nerve conduction velocity before and after surgery of both groups increased significantly at 2 week and 6 month after surgery ( P<0 . 05 ) . Compared to the control group, the sural nerve conduction velocity of treatment group increased significantly at 2 week and 6 month after surgery ( P<0 . 05 ) . Conclusion Autologus bone marrow stem cell transplantation com-bined Xuesaitong injection have a good effect in the treatment of diabetic peripheral neuropathy.