CAJ | 학술논문

目的：探讨糖皮质激素布地奈德混悬液雾化吸入对慢性阻塞性肺疾病急性加重期（ AECOPD ）患者诱导痰中嗜酸性粒细胞（ EOS）、嗜酸性粒细胞阳离子蛋白（ ECP）水平及肺功能的影响。方法选取支气管舒张试验阳性（阳性组）及阴性（阴性组） AECOPD患者，各40例。两组均给予布地奈德混悬液雾化吸入治疗，观察治疗前、后肺功能及诱导痰中EOS、ECP变化情况。结果两组治疗后第1秒最大呼气容积（ FEV1）、FEV 1所占肺活量（ FVC）百分比（ FEV 1／FVC）指标均高于治疗前（ P ＜0．01）；两组治疗前、后同期比较，阳性组EOS、ECP均高于阴性组（ P ＜0．01），两组治疗后 EOS、ECP均低于治疗前（ P＜0．05或P ＜0．01）。结论支气管舒张试验阳性AECOPD患者诱导痰中EOS、ECP均较阴性患者高，布地奈德混悬液雾化吸入治疗对支气管舒张试验阴性及阳性AECOPD患者均能使诱导痰中EOS及ECP水平下降，并利于改善肺功能。
목적：탐토당피질격소포지내덕혼현액무화흡입대만성조새성폐질병급성가중기（ AECOPD ）환자유도담중기산성립세포（ EOS）、기산성립세포양리자단백（ ECP）수평급폐공능적영향。방법선취지기관서장시험양성（양성조）급음성（음성조） AECOPD환자，각40례。량조균급여포지내덕혼현액무화흡입치료，관찰치료전、후폐공능급유도담중EOS、ECP변화정황。결과량조치료후제1초최대호기용적（ FEV1）、FEV 1소점폐활량（ FVC）백분비（ FEV 1／FVC）지표균고우치료전（ P ＜0．01）；량조치료전、후동기비교，양성조EOS、ECP균고우음성조（ P ＜0．01），량조치료후 EOS、ECP균저우치료전（ P＜0．05혹P ＜0．01）。결론지기관서장시험양성AECOPD환자유도담중EOS、ECP균교음성환자고，포지내덕혼현액무화흡입치료대지기관서장시험음성급양성AECOPD환자균능사유도담중EOS급ECP수평하강，병리우개선폐공능。
Objective To investigate eosinophils (EOS),eosinophil cationic protein (ECP) level in induced sputum and the effect of the glucocorticoid budesonide inhalation on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and pul-monary function .Mtehods Forty AECOPD patients with bronchial dilation test positive ( positive group ) and negative ( negative group) were selected ( n =40 each) and both the groups were given budesonide atomization inhalation treatment ,and changes of pul-monary function and EOS and ECP levels in induced sputum before and after treatment were observed .Rseults Scores of the first sec-ond maximum exhalation volume FEV 1 ,FVC and FEV1/FVC of the two groups after treatment were higher than that before treatment (P <0.01),EOS and ECP levels of the positive group compared before and after treatment were higher than that of the negative group ( P <0.01)and EOS and ECP levels after treatment in the two groups were lower than that before treatment ( P <0.05 or P <0.01). Conclusion EOS and ECP levels in induced sputum of positive AECOPD patients in bronchial dilation test are higher than that of neg -ative AECOPD patients.Budesonide atomization inhalation in the treatment of diastolic test of negative and positive AECOPD patients can regulate EOS in induced sputum and decrease EOS and ECP levels and improve the pulmonary function of the patients .