CAJ | 학술논문

目的：分析2型糖尿病肾病（ T2DN）患者疾病相关危险因素，探讨其与T2DN发生、发展的相关性。方法将300例T2DM患者根据尿白蛋白排泄率（ UAER）不同分为三组，即A组101例、B组105例和C组94例。观察各组间相关指标的变化情况，分析与疾病的相关性。结果三组患者在性别、年龄、体重指数（BMI）、空腹血糖（FBG）、餐后2 h血糖（2 h PG）方面比较差异均无统计学意义（ P ＞0．05）；B组与C组患者病程长于A组（ P ＜0．05），HbA1c高于A组（ P ＜0．05）；B组患者尿素氮（BUN）、SCr、尿酸（UA）和UMA指标均高于A组（ P ＜0．05）；C组患者BUN、SCr、UA和UMA指标均高于A组和B组（ P ＜0．05）。 Logistic回归分析显示，病程、HbA1c、SCr、UA和UAER是T2DN的相关危险因素。结论病程、HbA1c、SCr、UA与T2DN的发生、发展有密切关系，病程、HbA1c、SCr、UA与UAER呈正相关性。
목적：분석2형당뇨병신병（ T2DN）환자질병상관위험인소，탐토기여T2DN발생、발전적상관성。방법장300례T2DM환자근거뇨백단백배설솔（ UAER）불동분위삼조，즉A조101례、B조105례화C조94례。관찰각조간상관지표적변화정황，분석여질병적상관성。결과삼조환자재성별、년령、체중지수（BMI）、공복혈당（FBG）、찬후2 h혈당（2 h PG）방면비교차이균무통계학의의（ P ＞0．05）；B조여C조환자병정장우A조（ P ＜0．05），HbA1c고우A조（ P ＜0．05）；B조환자뇨소담（BUN）、SCr、뇨산（UA）화UMA지표균고우A조（ P ＜0．05）；C조환자BUN、SCr、UA화UMA지표균고우A조화B조（ P ＜0．05）。 Logistic회귀분석현시，병정、HbA1c、SCr、UA화UAER시T2DN적상관위험인소。결론병정、HbA1c、SCr、UA여T2DN적발생、발전유밀절관계，병정、HbA1c、SCr、UA여UAER정정상관성。
Objective To investigate the related risk factors of Type-2 Diabetes Nephropathy(T2DN).Methods Three hun-dred T2DN patients were divided into three groups;group A ( n =101), group B ( n =105) and group C ( n =94) according to UAER of the patients and relevant index change was observed and relevant factors of the disease were analyzed .Results There was no difference of statistical significance in the gender , age, BMI, FBG and 2h PBG among the three groups ( P <0.05), the courses of disease of group B and C were longer than that of group A ( P <0.05) , HbA1c was higher than that of group A ( P <0.05),and BUN, SCr, UA and UMA of group C were higher than that of group A and B ( P <0.05).As shown by non-conditional Logistic re-gression analysis,the course of disease,HbA1c,SCr, UA and UAER were the relevant risk factors of T2DN.Conclusion The course of disease,HbA1c,SCr,and UA are closely related to the occurrence and development of T 2DN,and the course of disease ,HbA1c,SCr, and UA are positively correlated with UAER .