北京大学学报(医学版)
北京大學學報(醫學版)
북경대학학보(의학판)
JOURNAL OF BEIJING MEDICAL UNIVERSITY(HEALTH SCIENCES)
2015年
1期
155-159
,共5页
载脂蛋白A-Ⅰ%肾肿瘤%免疫组织化学%生物学标记
載脂蛋白A-Ⅰ%腎腫瘤%免疫組織化學%生物學標記
재지단백A-Ⅰ%신종류%면역조직화학%생물학표기
Apolipoprotein A-Ⅰ%Kidney neoplasms%Immunohistochemistry%Biological markers
目的:研究载脂蛋白A-Ⅰ( apolipoprotein A-Ⅰ,ApoA-Ⅰ)在8种不同组织学分型的肾肿瘤组织中的表达情况,探索用于鉴别诊断的新型肿瘤标志物。方法:应用免疫组织化学方法检测23例肾肿瘤(包括透明细胞癌11例、乳头状细胞癌1例、嫌色细胞癌3例、嗜酸细胞腺癌1例、多房性囊性细胞癌2例、肾盂尿路移行上皮癌3例、后肾腺癌1例、集合管癌1例)及5例癌旁正常组织中ApoA-Ⅰ的表达,癌旁正常组织取自除外23例肾癌组织的其他5例肾肿瘤的切缘外非癌组织。结果:23例肾肿瘤中,ApoA-Ⅰ阳性21例(阳性率91.3%);肾癌旁组织5例,阳性2例(阳性率40.0%),ApoA-Ⅰ在肿瘤组织与癌旁正常组织中的表达差异有统计学意义(Z=-2.829,P=0.003)。比较不同组织学分型的肾肿瘤,11例肾透明细胞癌中,阳性9例(阳性率81.8%), ApoA-Ⅰ的表达程度与肿瘤细胞的恶性程度有关,透明细胞癌Ⅱ级、Ⅲ级的表达程度明显高于Ⅰ级,差异有统计学意义(Z=-2.070,P=0.038);乳头状细胞癌、嫌色细胞癌、嗜酸细胞腺癌、多房性囊性细胞癌、肾盂尿路移行上皮癌、后肾腺癌、集合管癌均有不同程度的阳性着色。结论:ApoA-Ⅰ在肾肿瘤组织中的表达特异升高,可作为区分不同组织学分型肾肿瘤的免疫组织化学标志物。
目的:研究載脂蛋白A-Ⅰ( apolipoprotein A-Ⅰ,ApoA-Ⅰ)在8種不同組織學分型的腎腫瘤組織中的錶達情況,探索用于鑒彆診斷的新型腫瘤標誌物。方法:應用免疫組織化學方法檢測23例腎腫瘤(包括透明細胞癌11例、乳頭狀細胞癌1例、嫌色細胞癌3例、嗜痠細胞腺癌1例、多房性囊性細胞癌2例、腎盂尿路移行上皮癌3例、後腎腺癌1例、集閤管癌1例)及5例癌徬正常組織中ApoA-Ⅰ的錶達,癌徬正常組織取自除外23例腎癌組織的其他5例腎腫瘤的切緣外非癌組織。結果:23例腎腫瘤中,ApoA-Ⅰ暘性21例(暘性率91.3%);腎癌徬組織5例,暘性2例(暘性率40.0%),ApoA-Ⅰ在腫瘤組織與癌徬正常組織中的錶達差異有統計學意義(Z=-2.829,P=0.003)。比較不同組織學分型的腎腫瘤,11例腎透明細胞癌中,暘性9例(暘性率81.8%), ApoA-Ⅰ的錶達程度與腫瘤細胞的噁性程度有關,透明細胞癌Ⅱ級、Ⅲ級的錶達程度明顯高于Ⅰ級,差異有統計學意義(Z=-2.070,P=0.038);乳頭狀細胞癌、嫌色細胞癌、嗜痠細胞腺癌、多房性囊性細胞癌、腎盂尿路移行上皮癌、後腎腺癌、集閤管癌均有不同程度的暘性著色。結論:ApoA-Ⅰ在腎腫瘤組織中的錶達特異升高,可作為區分不同組織學分型腎腫瘤的免疫組織化學標誌物。
목적:연구재지단백A-Ⅰ( apolipoprotein A-Ⅰ,ApoA-Ⅰ)재8충불동조직학분형적신종류조직중적표체정황,탐색용우감별진단적신형종류표지물。방법:응용면역조직화학방법검측23례신종류(포괄투명세포암11례、유두상세포암1례、혐색세포암3례、기산세포선암1례、다방성낭성세포암2례、신우뇨로이행상피암3례、후신선암1례、집합관암1례)급5례암방정상조직중ApoA-Ⅰ적표체,암방정상조직취자제외23례신암조직적기타5례신종류적절연외비암조직。결과:23례신종류중,ApoA-Ⅰ양성21례(양성솔91.3%);신암방조직5례,양성2례(양성솔40.0%),ApoA-Ⅰ재종류조직여암방정상조직중적표체차이유통계학의의(Z=-2.829,P=0.003)。비교불동조직학분형적신종류,11례신투명세포암중,양성9례(양성솔81.8%), ApoA-Ⅰ적표체정도여종류세포적악성정도유관,투명세포암Ⅱ급、Ⅲ급적표체정도명현고우Ⅰ급,차이유통계학의의(Z=-2.070,P=0.038);유두상세포암、혐색세포암、기산세포선암、다방성낭성세포암、신우뇨로이행상피암、후신선암、집합관암균유불동정도적양성착색。결론:ApoA-Ⅰ재신종류조직중적표체특이승고,가작위구분불동조직학분형신종류적면역조직화학표지물。
Objective:To investigate the expression of apolipoprotein A-Ⅰ( ApoA-Ⅰ) in eight histo-logical types of renal neoplasms and to explore a new biomarker for differential diagnosis .Methods:The immunochemistry was used to detect the expression of ApoA-Ⅰ in 23 cases of renal tumors , including clear cell carcinoma , papillary cell carcinoma , chromophobe cell carcinoma , oncocytoma , multilocular cystic carcinoma , renal pelvis invasive urothelial carcinoma , metanephric adenoma and collecting ducts carcinoma.Five cases of cancer-adjacent normal tissues were obtained from another five renal tumor pa-tients and were chosen as control group .Results: In the 23 cases of renal tumors , ApoA-Ⅰ was ex-pressed in 21 cases(positive rate was 91.3%).There were only two in five cases of normal tissues which expressed this protein ( positive rate was 40 .0%) .A significant differentiation was observed between the two groups(Z=-2.829,P=0.003).In renal clear cell carcinoma(RCC), ApoA-Ⅰ expression level was correlated with the grade and stage of tumor tissues .ApoA-Ⅰ was stained much more stronger in RCCⅡ-Ⅲ than in RCCⅠ( Z=-2.070,P=0.038).In various histological types of renal cancer , ApoA-Ⅰwas all expressed to some degrees .Conclusion:ApoA-Ⅰcan be chosen as a tumor biomarker to differentiate various histological types of renal neoplasms .