CAJ | 학술논문

目的：探讨诱导痰过敏毒素C5a在支气管哮喘中的变化特点。方法：2006年9月至2007年2月门诊和病房就诊的哮喘患者，急性发作组33例，经过临床治疗进入缓解期组25例，失访8例；对照组13例。患者在入选及回访时均测定肺功能，诱导痰进行分类计数，测定诱导痰上清液中C5 a水平。结果：哮喘急性发作期诱导痰中C5a水平高于治疗后临床缓解期水平[0．85（0．68～2．13）μg／L vs．0．45（0．26～0．88）μg／L，Z＝－2．193，P ＝0．013]，且临床缓解期C5a水平高于对照组[0．14（0．06～0．45）μg／L，Z＝－2．141，P＝0．015]。轻、中、重度哮喘急性发作期C5a水平依次升高，分别为0．34（0．17～0．63）μg／L、0．85（0．55～1．67）μg／L、2．21（1．27～9．0）μg／L，差异有统计学意义（χ2＝12．330，P＝0．001）。哮喘急性发作期患者诱导痰C5a水平与诱导痰细胞总数、中性粒细胞计数、巨噬细胞计数呈正相关（r＝0．797，P＝0．004；r＝0．504，P＝0．032；r＝0．424，P＝0．036）。结论：过敏毒素C5 a作为先天免疫系统的重要组成部分，参与哮喘的发病，在哮喘慢性气道炎症中起促进作用。
목적：탐토유도담과민독소C5a재지기관효천중적변화특점。방법：2006년9월지2007년2월문진화병방취진적효천환자，급성발작조33례，경과림상치료진입완해기조25례，실방8례；대조조13례。환자재입선급회방시균측정폐공능，유도담진행분류계수，측정유도담상청액중C5 a수평。결과：효천급성발작기유도담중C5a수평고우치료후림상완해기수평[0．85（0．68～2．13）μg／L vs．0．45（0．26～0．88）μg／L，Z＝－2．193，P ＝0．013]，차림상완해기C5a수평고우대조조[0．14（0．06～0．45）μg／L，Z＝－2．141，P＝0．015]。경、중、중도효천급성발작기C5a수평의차승고，분별위0．34（0．17～0．63）μg／L、0．85（0．55～1．67）μg／L、2．21（1．27～9．0）μg／L，차이유통계학의의（χ2＝12．330，P＝0．001）。효천급성발작기환자유도담C5a수평여유도담세포총수、중성립세포계수、거서세포계수정정상관（r＝0．797，P＝0．004；r＝0．504，P＝0．032；r＝0．424，P＝0．036）。결론：과민독소C5 a작위선천면역계통적중요조성부분，삼여효천적발병，재효천만성기도염증중기촉진작용。
Objective:To investigate the role of anaphylatoxin C 5 a in patients with asthma .Methods:A prospective study was performed between September 2006 and February 2007.A total of 33 patients with acute exacerbation of asthma and 13 healthy subjects were recruited into the study .The patients with acute exacerbation of asthma were also studied when they returned to the remission state .Levels of lung function, levels of C5a in induced sputum and cell differential count in induced sputum were determined . Results:The level of C5 a in induced sputum was significantly higher in patients with acute exacerbation of asthma [0.85(0.68-2.13) μg/L] than that in patients with stable asthma [0.45(0.26-0.88)μg/L, Z=-2.193, P=0.013];Sputum C5a levels in stable asthma patients were significantly higher than those in healthy controls [0.14(0.06-0.45) μg/L, Z=-2.141, P=0.015].The level of C5a in patients with severe exacerbation [2.21(1.27 -9.0) μg/L] was significantly higher than those in patients with mild exacerbation [0.34(0.17-0.63) μg/L] and moderate exacerbation [0.85(0.55-1.67) μg/L,χ2 =12.330, P=0.001].The level of C5a in induced sputum was positively correlated with the number of total cells count (r=0.797, P=0.004), neutrophils (r=0.504, P=0.032) and macrophages ( r =0.424, P=0.036 ) in acute exacerbation of asthma .Conclusion: C5a levels in induced sputum could be identified as an important prognostic biomarker , which involved in asthma ’ s pathogenesis .