CAJ | 학술논문

目的：研究组胺作用于腹外侧视前区对大鼠睡眠-觉醒周期的影响。方法通过脑立体定位、腹外侧视前区微量注射组胺，脑电图仪记录及分析睡眠、觉醒时相。结果微量注射50μmol/L组胺无明显影响，而100μmol/L组胺显著减少大鼠睡眠，增加觉醒。结论组胺在腹外侧视前区对大鼠睡眠-觉醒周期发挥重要的调节作用，具有明显的促觉醒作用。
목적：연구조알작용우복외측시전구대대서수면-각성주기적영향。방법통과뇌입체정위、복외측시전구미량주사조알，뇌전도의기록급분석수면、각성시상。결과미량주사50μmol/L조알무명현영향，이100μmol/L조알현저감소대서수면，증가각성。결론조알재복외측시전구대대서수면-각성주기발휘중요적조절작용，구유명현적촉각성작용。
Objective To study the effect of histamine in rat ventrolateral preoptic area on sleep-wakeful?ness cycle. Methods Histamine was microinjected into ventrolateral preoptic area through stereotaxic technique,sleeping and waking time phases were recorded and analyzed by electroencephalograph. Results Microinjection of 50 μmol/L histamine had no significant effect ,but 100 μmol/L histamine de?creased sleeping time and increased waking time significantly. Conclusion Histamine is involved in reg?ulation of sleep-waking cycle and promotes wakefulness significantly in the ventrolateral preoptic area.