CAJ | 학술논문

目的：建立基于肾上腺切除＋自体大网膜移植的雄激素全阻断大鼠模型，为临床上实现真正意义上的雄激素全阻断治疗前列腺癌提供理论和实验依据。方法将32只成年雄性SD大鼠随机分为4组各8只，A组：双侧睾丸切除＋双侧肾上腺切除＋肾上腺皮质组织块自体大网膜移植；B组：双侧睾丸切除；C组：双侧肾上腺切除＋肾上腺皮质组织块自体大网膜移植；D组：假手术组。术后7周检测肾上腺移植体、前列腺生长情况及大网膜（含肾上腺移植体）激素分泌水平。结果术后7周，A、C组大鼠肾上腺皮质组织块在大网膜上存活、再生，在组织形态学上有球状带、网状带、束状带细胞，但细胞排列较不规则。 A组大鼠前列腺大体完全萎缩，组织学上腺泡明显萎缩，腔体皱缩，腺体分泌物减少，B、C组次之。 A组和C组大网膜组织内的皮质醇、皮质酮及醛固酮水平均显著高于B组和D组（均P＜0．001）。结论双侧睾丸切除＋双侧肾上腺切除＋肾上腺皮质自体大网膜移植既能相对彻底地阻断雄激素，又能最大限度地保留肾上腺皮质功能，在内分泌治疗晚期前列腺癌时具有一定的潜力。
목적：건립기우신상선절제＋자체대망막이식적웅격소전조단대서모형，위림상상실현진정의의상적웅격소전조단치료전렬선암제공이론화실험의거。방법장32지성년웅성SD대서수궤분위4조각8지，A조：쌍측고환절제＋쌍측신상선절제＋신상선피질조직괴자체대망막이식；B조：쌍측고환절제；C조：쌍측신상선절제＋신상선피질조직괴자체대망막이식；D조：가수술조。술후7주검측신상선이식체、전렬선생장정황급대망막（함신상선이식체）격소분비수평。결과술후7주，A、C조대서신상선피질조직괴재대망막상존활、재생，재조직형태학상유구상대、망상대、속상대세포，단세포배렬교불규칙。 A조대서전렬선대체완전위축，조직학상선포명현위축，강체추축，선체분비물감소，B、C조차지。 A조화C조대망막조직내적피질순、피질동급철고동수평균현저고우B조화D조（균P＜0．001）。결론쌍측고환절제＋쌍측신상선절제＋신상선피질자체대망막이식기능상대철저지조단웅격소，우능최대한도지보류신상선피질공능，재내분비치료만기전렬선암시구유일정적잠력。
Objective To establish androgen deprivation rat modeling by removing rat testicles and bilateral adrenalines and autologous ectopic transplanting so as to obtain scientific knowledge for treating prostate cancer .Methods 32 SA rats were randomly divided into four groups , namely, group A, B, C, and D.Treatment for group A included removal of testicles , removal of bilateral adrenal , and transplanting adrenal cortical tissue under autologous epiploon .Treatment for group B included removal rat testicles .Treatment for group C included removal of bilateral adrenalines and implanting adrenal cortical tissue under autologous epiploon .Treatment for group D included sham operation .Findings The prostate of group A atrophied evidently , greater omentum implant survived and regenerated with endocrine function .Conclusion Androgen deprivation by means of removal of testicles and bilateral adrenalines and autologous epiploon transplanting can make an effective method for treating prostate cancer .