CAJ | 학술논문

目的：研究杜仲子的毒性大小，及其与杜仲皮的毒性比较，为其进一步开发利用提供依据。方法通过小鼠的急性毒性实验、骨髓微核实验、精子畸形实验、大鼠的慢性毒性实验来研究杜仲子的毒性大小和与杜仲皮的毒性比较。结果小鼠的急性毒性实验中，给药组都无小鼠死亡；小鼠骨髓微核实验及精子畸形实验中，杜仲子和杜仲皮与正常组对比在统计学中无差异。大鼠的慢性毒性实验中，杜仲子及杜仲皮可以影响食物利用率、血常规和肝功能，还可以影响肝、脾、睾丸、卵巢的脏体系数；对大鼠脏器进行病理组织学检查，未见明显异常。杜仲子与杜仲皮的毒性比较无差异。结论杜仲子和杜仲在急性毒性实验、骨髓微核实验、精子畸形实验中显示无毒性；在慢性毒性实验中，杜仲子和杜仲会影响食物利用率、血常规和肝功能，也会影响肝、脾、睾丸、卵巢生长，有慢性毒性。但杜仲子与杜仲皮的毒性无差异。
목적：연구두중자적독성대소，급기여두중피적독성비교，위기진일보개발이용제공의거。방법통과소서적급성독성실험、골수미핵실험、정자기형실험、대서적만성독성실험래연구두중자적독성대소화여두중피적독성비교。결과소서적급성독성실험중，급약조도무소서사망；소서골수미핵실험급정자기형실험중，두중자화두중피여정상조대비재통계학중무차이。대서적만성독성실험중，두중자급두중피가이영향식물이용솔、혈상규화간공능，환가이영향간、비、고환、란소적장체계수；대대서장기진행병리조직학검사，미견명현이상。두중자여두중피적독성비교무차이。결론두중자화두중재급성독성실험、골수미핵실험、정자기형실험중현시무독성；재만성독성실험중，두중자화두중회영향식물이용솔、혈상규화간공능，야회영향간、비、고환、란소생장，유만성독성。단두중자여두중피적독성무차이。
Objective: To comparatively study the toxicity of Eucommia ulmoides seed and bark, provide the basis for its further utilization. Methods:By acute toxicity test, bone marrow of mice micro nuclear test, sperm deformity and chronic toxicity experiments, the toxicity of E. ulmoides seed and bark was compared. Results:There were no dead mice in acute toxicity experiment and no significant difference between E. ulmoides seed and bark in bone marrow micro nuclear test. In chronic toxicity experiments, E. ulmoides seed and bark affected the utilization rate of food, the routine blood and liver function, and the organ coefficient of the liver, spleen, testis and ovary, but there were no obvious abnormalities in histologic examination. Conclusion: Three were no significant difference in toxicity between E. ulmoides seed and bark.