CAJ | 학술논문

目的：探讨重症肺炎患儿凝血指标与降钙素原(PCT)的变化。方法选取重症肺炎患儿76例，根据PCT升高的程度分为2组，PCT<2.00 ng/ml组和PCT≥2.00 ng/ml组；另选择30例健康儿童作为正常对照组。检测并分析比较各组的PCT、血小板计数(PLT)、抗凝血酶Ⅲ(AT-Ⅲ)活性和D-二聚体(DD)水平。结果与对照组比较，重症肺炎组PCT、PLT、DD水平明显升高，AT-Ⅲ活性明显降低，差异均有统计学意义(P<0.05)；PCT≥2.00 ng/ml组的AT-Ⅲ活性和PLT水平相比PCT<2.00 ng/ml组更低，而DD水平更高，差异均有统计学意义(P<0.05)；PCT≥2.00 ng/ml组的DIC发生率(33.33%)高于PCT<2.00 ng/ml组(9.09%)，差异有统计学意义(校正χ2=5.02，P=0.025)。结论重症肺炎患儿易发生凝血纤溶功能障碍，PCT水平越高，凝血纤溶功能紊乱越明显，越容易并发弥散性血管内凝血。
목적：탐토중증폐염환인응혈지표여강개소원(PCT)적변화。방법선취중증폐염환인76례，근거PCT승고적정도분위2조，PCT<2.00 ng/ml조화PCT≥2.00 ng/ml조；령선택30례건강인동작위정상대조조。검측병분석비교각조적PCT、혈소판계수(PLT)、항응혈매Ⅲ(AT-Ⅲ)활성화D-이취체(DD)수평。결과여대조조비교，중증폐염조PCT、PLT、DD수평명현승고，AT-Ⅲ활성명현강저，차이균유통계학의의(P<0.05)；PCT≥2.00 ng/ml조적AT-Ⅲ활성화PLT수평상비PCT<2.00 ng/ml조경저，이DD수평경고，차이균유통계학의의(P<0.05)；PCT≥2.00 ng/ml조적DIC발생솔(33.33%)고우PCT<2.00 ng/ml조(9.09%)，차이유통계학의의(교정χ2=5.02，P=0.025)。결론중증폐염환인역발생응혈섬용공능장애，PCT수평월고，응혈섬용공능문란월명현，월용역병발미산성혈관내응혈。
Objective To explore the changes in the levels of coagulation indicators and procalcitonin (PCT) in children with severe pneumonia. Methods A total of 76 children with severe pneumonia were selected and were divided into two groups according to the level of PCT, PCT<2.00 ng/ml group and PCT≥2.00 ng/ml group. Thirty healthy children were selected as normal controls. The levels of PCT, platelet counts (PLT), antithrombin-Ⅲ(AT-Ⅲ) activity and D-dimer (DD) were measured and compared among groups. Results Compared with control group, PCT, PLT and DD levels were signiifcantly higher and AT- Ⅲactivity was signiifcantly lower in severe pneumonia group (P<0.05). AT- Ⅲactivity and PLT were signiifcantly lower and DD level was signiifcantly higher in PCT≥2.00 ng/ml group than those in PCT<2.00 ng/ml group (P<0.05). The incidence of disseminated intravascular coagulation (DIC) in PCT≥2.00ng/ml group was signiifcantly higher than that in PCT<2.00ng/ml group (33.33%vs. 9.09%, correctedχ2=5.02, P=0.025). Conclusions There is dysfunction of coagulation in children with severe pneumonia. The higher level of PCT is, more obvious coagulation dysfunction is. The severe pneumonia children with high level of PCT are more likely to be complicated with disseminated inravascular coagulation.