生理科学进展
生理科學進展
생이과학진전
PROGRESS IN PHYSIOLOGICAL SCIENCES
2015年
1期
1-5
,共5页
激素敏感性脂肪酶%生殖系统%睾丸%脂肪组织%脂肪分解
激素敏感性脂肪酶%生殖繫統%睪汍%脂肪組織%脂肪分解
격소민감성지방매%생식계통%고환%지방조직%지방분해
hormone-sensitive lipase%reproductive system%testis%adipose tissue%lipolysis
激素敏感性脂肪酶被认为是经典的脂肪分解限速酶，可特异水解甘油三酯，受儿茶酚胺等激素调控。近年来研究表明：HSL 作用底物不仅有甘油三酯，还包括甘油二酯、甘油一酯、胆固醇酯等。然而，脂肪酶在生殖系统的功能并不清楚，基因敲除小鼠为证实 HSL 广泛存在于生殖系统提供良好模型，提示其可能在生殖系统生理及病理生理过程发挥重要调节作用，本文将着重介绍生殖系统中 HSL 基因与蛋白质结构并总结其在生殖系统的功能。
激素敏感性脂肪酶被認為是經典的脂肪分解限速酶，可特異水解甘油三酯，受兒茶酚胺等激素調控。近年來研究錶明：HSL 作用底物不僅有甘油三酯，還包括甘油二酯、甘油一酯、膽固醇酯等。然而，脂肪酶在生殖繫統的功能併不清楚，基因敲除小鼠為證實 HSL 廣汎存在于生殖繫統提供良好模型，提示其可能在生殖繫統生理及病理生理過程髮揮重要調節作用，本文將著重介紹生殖繫統中 HSL 基因與蛋白質結構併總結其在生殖繫統的功能。
격소민감성지방매피인위시경전적지방분해한속매，가특이수해감유삼지，수인다분알등격소조공。근년래연구표명：HSL 작용저물불부유감유삼지，환포괄감유이지、감유일지、담고순지등。연이，지방매재생식계통적공능병불청초，기인고제소서위증실 HSL 엄범존재우생식계통제공량호모형，제시기가능재생식계통생리급병리생리과정발휘중요조절작용，본문장착중개소생식계통중 HSL 기인여단백질결구병총결기재생식계통적공능。
Hormone-sensitive lipase (HSL)has long been considered as a classical rate-limiting enzyme during lipolysis since it was first described in 1 960s.HSL is regulated mainly by catecholamine,inclu-ding adrenalin.Studies in recent years indicated that the substrates for HSL are not only triglycerides, but also diacylglycerol with the catalytic activity is ten times that of triglycerides,glycerol esters and cho-lesterol esters,which overthrow the opinion that HSL is specific to triglyceride.The scientists have gener-ated HSL gene knockout mice and confirmed HSL is widely located in the reproductive system,which in-dicates that HSL may play an important role in the regulation of physiological and pathophysiological process in the reproductive system.Here,we will focus on the features of the HSL gene,mRNA and its protein,and summarize the HSL functions in the reproductive system.
