CAJ | 학술논문

目的：探讨吲哚美辛栓对内镜逆行胆管造影（ ERCP ）术后急性胰腺炎的预防作用及其可能机制。方法收集2013年3月～2014年5月拟行ERCP的患者240例，随机分为两组：对照组120例，予以常规处理。预防组120例，在常规处理的基础上，ERCP术前0．5 h，术后1 h分别予以吲哚美辛栓肛门塞入。监测血淀粉酶水平，同时观察胰腺炎的发生情况。结果预防组术后6h，12h和24h血清淀粉酶水平均低于对照组（ P＜0．05）。对照组发生ERCP术后急性胰腺炎9例，其中轻症胰腺炎8例，给予常规抑酸抑酶抗感染等治疗后好转，重症胰腺炎1例，经积极抢救后好转。预防组无急性胰腺炎患者。两组急性胰腺炎发生率比较有统计学差异（P＜0．05）。结论吲哚美辛栓对ERCP后高淀粉酶血症，急性胰腺炎有预防作用，且较安全。
목적：탐토신타미신전대내경역행담관조영（ ERCP ）술후급성이선염적예방작용급기가능궤제。방법수집2013년3월～2014년5월의행ERCP적환자240례，수궤분위량조：대조조120례，여이상규처리。예방조120례，재상규처리적기출상，ERCP술전0．5 h，술후1 h분별여이신타미신전항문새입。감측혈정분매수평，동시관찰이선염적발생정황。결과예방조술후6h，12h화24h혈청정분매수평균저우대조조（ P＜0．05）。대조조발생ERCP술후급성이선염9례，기중경증이선염8례，급여상규억산억매항감염등치료후호전，중증이선염1례，경적겁창구후호전。예방조무급성이선염환자。량조급성이선염발생솔비교유통계학차이（P＜0．05）。결론신타미신전대ERCP후고정분매혈증，급성이선염유예방작용，차교안전。
[ ABSTRACT] Objective To explore prevention of indole beauty XinShuan on acute pancreatitis after ERCP and its possible mechanisms .Methods Two hundred and forty cases of ERCP patients from May 2014 to March 2013 were collected and randomly divided into two groups:normal group of 120 cases,normal processing .Prevention group of 120 cases,on the basis of routine treatment ,ERCP preoperatively 0.5h,postoperative 1h indole beauty XinShuan anal in-jection respectively .Monitoring the blood amylase levels ,while observing the occurrence of acute pancreatitis .Results The serum amylase level of prevention group and the control group ERCP preoperative and postoperative was showed in table 2,according to the results of postoperative in prevention group ,6h,12h and 24h serum amylase level were lower than that in control group(P<0.05).Nine cases of acute pancreatitis after ERCP were found in control group ,of which 8 cases of mild pancreatitis ,conventional acid suppression antimicrobial enzymes were given and the infection improved after treatment ,such as the one severe acute pancreatitis .Patients in prevention group were all without acute pancreatitis . The difference of incidence of acute pancreatitis between the two groups was statistically significant (P<0.05).Conclu-sion Indole beauty XinShuan has prevention effect on high blood amylase and acute pancreatitis after ERCP .