CAJ | 학술논문

目的：探讨电针丰隆穴对高脂血症大鼠肝脏组织炎症细胞因子的调控作用。方法：将30只健康SD大鼠随机分为正常组、模型组、电针组各10只。电针组给予丰隆穴电针治疗。4周后，检测各组大鼠血脂水平，即总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL‐C）、高密度脂蛋白胆固醇（HDL‐C）含量，ELISA检测各组大鼠肝脏组织中肿瘤坏死因子‐α（T N F‐α）、白细胞介素‐1β（IL‐1β）、干扰素‐γ（IFN‐γ）蛋白水平变化。结果：治疗后，血脂水平比较，与正常组比较，模型组大鼠TC、TG及LDL‐C均显著升高（P＜0．01，0．05），HDL‐C显著降低（P＜0．05），电针组的TC、LDL‐C均显著升高（P＜0．01）。与模型组比较，电针组大鼠 TC、TG及 LDL‐C均显著降低（P＜0．01，0．05），HDL‐C显著升高（P＜0．05）。肝脏组织炎症因子蛋白水平比较，与正常组比较，模型组炎症因子T N F‐α、IL‐1β、IFN‐γ均有显著性升高（ P＜0．05，0．01 ），电针组炎症因子差异均无统计学意义。与模型组比较，电针组炎症因子均明显降低（P＜0．05，0．01）。结论：电针丰隆穴能够明显下调高脂血症大鼠血脂中 TC、LDL‐C水平，并能降低肝脏组织中炎症因子T N F‐α、IL‐1β、IFN‐γ的蛋白水平变化，对高脂血症具有一定的治疗作用。
목적：탐토전침봉륭혈대고지혈증대서간장조직염증세포인자적조공작용。방법：장30지건강SD대서수궤분위정상조、모형조、전침조각10지。전침조급여봉륭혈전침치료。4주후，검측각조대서혈지수평，즉총담고순（TC）、감유삼지（TG）、저밀도지단백담고순（LDL‐C）、고밀도지단백담고순（HDL‐C）함량，ELISA검측각조대서간장조직중종류배사인자‐α（T N F‐α）、백세포개소‐1β（IL‐1β）、간우소‐γ（IFN‐γ）단백수평변화。결과：치료후，혈지수평비교，여정상조비교，모형조대서TC、TG급LDL‐C균현저승고（P＜0．01，0．05），HDL‐C현저강저（P＜0．05），전침조적TC、LDL‐C균현저승고（P＜0．01）。여모형조비교，전침조대서 TC、TG급 LDL‐C균현저강저（P＜0．01，0．05），HDL‐C현저승고（P＜0．05）。간장조직염증인자단백수평비교，여정상조비교，모형조염증인자T N F‐α、IL‐1β、IFN‐γ균유현저성승고（ P＜0．05，0．01 ），전침조염증인자차이균무통계학의의。여모형조비교，전침조염증인자균명현강저（P＜0．05，0．01）。결론：전침봉륭혈능구명현하조고지혈증대서혈지중 TC、LDL‐C수평，병능강저간장조직중염증인자T N F‐α、IL‐1β、IFN‐γ적단백수평변화，대고지혈증구유일정적치료작용。
Objective:To study the modutory effect of electroacupuncture at the "Fenglong"on inflammatory fac‐tors in the livers of rat hyperlipidemia model .Methods :Thirty health male SD rats were selected and randomly di‐vided into 3 groups :normal control group (A) ,model control group (B) ,and electroacupuncture group (C) .After four weeks ,blood lipids of rats were determined .The protein levels of TNF‐α,IL‐1βand IFN‐γin the livers of rat hyperlipidemia model were detected by ELISA .Results:As compared with group A ,the contents of TC ,TG and LDL‐C were significantly increased (P<0 .01 ,or P<0 .05) and the content of HDL‐C was significantly decreased (P<0 .05) in group B ,and the contents of TC and LDL‐C were significantly increased in group C (P<0 .01) .As compared with group B ,the contents of TC ,TG and LDL‐C were significantly reduced (P<0 .01) ,and those of HDL‐C significantly increased in group C (P<0 .05) .As compared with group A ,TNF‐α,IL‐1βand IFN‐γlevels were increased significantly in group B (P<0 .05 ,and P<0 .01) .As compared with group B ,TNF‐α,IL‐1βand IFN‐γlevels in group C were decreased significantly (P<0 .05 ,and P<0 .01) .Conclusion:Electroacupuncture at "Fenglong"can notably decrease the levels of TC and LDL‐C ,and the protein levels of TNF‐α,IL‐1βand IFN‐γin the liver tissues ,suggesting its certain therapeutical effectiveness on hyperlipemia .