CAJ | 학술논문

目的：探讨超早期高压氧（HBO ）对大鼠局灶性脑缺血的梗死体积及脑组织含水量的影响。方法：将60只健康的SD大鼠随机分成假手术组、对照组和HBO组各20只，应用线栓法制作大鼠局灶性脑缺血模型，HBO组大鼠给予HBO治疗。各组大鼠均于缺血后12h断头取脑，比较各组脑梗死体积、脑组织水含量。结果：与对照组比较，HBO组梗死体积及脑组织含水量明显减少（ P＜0．05）。结论：超早期 HBO治疗能够减低脑水肿，减小脑梗死体积，进而促进神经功能的恢复、产生治疗作用。
목적：탐토초조기고압양（HBO ）대대서국조성뇌결혈적경사체적급뇌조직함수량적영향。방법：장60지건강적SD대서수궤분성가수술조、대조조화HBO조각20지，응용선전법제작대서국조성뇌결혈모형，HBO조대서급여HBO치료。각조대서균우결혈후12h단두취뇌，비교각조뇌경사체적、뇌조직수함량。결과：여대조조비교，HBO조경사체적급뇌조직함수량명현감소（ P＜0．05）。결론：초조기 HBO치료능구감저뇌수종，감소뇌경사체적，진이촉진신경공능적회복、산생치료작용。
Objective:To investigate the effect of ultra‐early hyperbaric oxygen therapy on focal cerebral ischemia of rats .Method:The thread‐occluded method was used to make middle cerebral artery occlusion (MCAO) model . Sixty Sprague‐Dawly rats were randomly divided into 3 groups :sham operated group ,ischemic control group and hyperbaric oxygen therapy group .The rats were killed 12 h after ischemia .The percentage of infarction (infarct ra‐tio) was calculated by dividing the infarct volume by total volume of the slices .Result:As compared with ischemic control group ,the percentage of infarction and brain water content were significantly reduced in hyperbaric oxygen therapy group (P<0 .05) .Conclusion:Ultra‐early hyperbaric oxygen therapy can treat cerebral ischemia effectively via reducing infarction volume and brain water content .