CAJ | 학술논문

目的：通过对不稳定型心绞痛（UAP）患者内皮功能及血尿酸（UA）的检测，探讨血管内皮功能与血尿酸之间的关系。方法对202例临床确诊为不稳定型心绞痛的患者，利用Endo-PAT 2000仪器采用外周动脉张力测定（PAT）技术评价血管内皮细胞功能，并计算血管反应性充血指数（RHI）。空腹抽取静脉血测定血尿酸水平,根据血尿酸水平将入选患者分为高尿酸血症组及尿酸正常组。结果高尿酸血症组男性性别比例高于尿酸正常组（73.17% vs.56.67%，P=0.018），尿酸正常组及高尿酸血症组间RHI值无统计学差异（Z=-0.811，P=0.417），血尿酸与RHI值无直线性相关关系（r=-0.097， P=0.169）。结论血尿酸指标不能作为不稳定型心绞痛患者血管内皮功能受损的早期预测指标。
목적：통과대불은정형심교통（UAP）환자내피공능급혈뇨산（UA）적검측，탐토혈관내피공능여혈뇨산지간적관계。방법대202례림상학진위불은정형심교통적환자，이용Endo-PAT 2000의기채용외주동맥장력측정（PAT）기술평개혈관내피세포공능，병계산혈관반응성충혈지수（RHI）。공복추취정맥혈측정혈뇨산수평,근거혈뇨산수평장입선환자분위고뇨산혈증조급뇨산정상조。결과고뇨산혈증조남성성별비례고우뇨산정상조（73.17% vs.56.67%，P=0.018），뇨산정상조급고뇨산혈증조간RHI치무통계학차이（Z=-0.811，P=0.417），혈뇨산여RHI치무직선성상관관계（r=-0.097， P=0.169）。결론혈뇨산지표불능작위불은정형심교통환자혈관내피공능수손적조기예측지표。
Objective To discuss the relationship between vascular endothelial function and blood uric acid (BUA) in patients with unstable angina pectoris (UAP). Methods Vascular endothelial function was reviewed and reactive hyperemia index (RHI) was calculated by using peripheral arterial tension (PAT) detection with Endo-PAT 2000 (Itamar Medical Inc., Caesarea, Isarel) in UAP patients (n=202). All patients were divided into high BUA group and normal BUA group according to fast venous BUA level. Results The percentage of male cases was higher in high BUA group than that in normal BUA group (73.17%vs. 56.67%, P=0.018). RHI had no statistical difference (Z=-0.811, P=0.417) between 2 groups, and BUA and RHI had no linear correlation (r=-0.097, P=0.169). Conclusion BUA cannot be taken as early-stage predictive index for injured vascular endothelial function in UAP patients.