CAJ | 학술논문

目的：观察半乳糖凝集素3（Gal-3）在心肌梗死后心力衰竭患者的表达水平。方法纳入心力衰竭患者60例，根据其既往病史，分为陈旧性心肌梗死组（n=30）和非心肌梗死组（n=30）,采用超声心动图评价患者心脏结构和心功能，采用ELISA试剂盒检测患者血浆Gal-3水平，比较两组Gal-3水平差别，并分析Gal-3水平与左室射血分数（LVEF）的相关性。结果陈旧性心肌梗死组患者Gal-3表达水平显著高于非心肌梗死组[（28.88±9.78）ng/ml vs.（22.57±4.59）ng/ml]，差异有统计学意义（P＜0.05）。心肌梗死组患者LVEF显著低于非心肌梗死组[（51.38±9.75）%vs.（58.90±4.62）%]，差异有统计学意义（P＜0.05）。血浆Gal-3表达水平与左心房内径呈正相关（r=0.612，P＜0.01），与LVEF呈负相关（r=-0.389，P＜0.05）。结论心肌梗死心力衰竭患者血浆Gal-3的表达水平更高，血浆Gal-3表达水平与其左心房内径呈正相关，与左心室射血分数呈负相关。
목적：관찰반유당응집소3（Gal-3）재심기경사후심력쇠갈환자적표체수평。방법납입심력쇠갈환자60례，근거기기왕병사，분위진구성심기경사조（n=30）화비심기경사조（n=30）,채용초성심동도평개환자심장결구화심공능，채용ELISA시제합검측환자혈장Gal-3수평，비교량조Gal-3수평차별，병분석Gal-3수평여좌실사혈분수（LVEF）적상관성。결과진구성심기경사조환자Gal-3표체수평현저고우비심기경사조[（28.88±9.78）ng/ml vs.（22.57±4.59）ng/ml]，차이유통계학의의（P＜0.05）。심기경사조환자LVEF현저저우비심기경사조[（51.38±9.75）%vs.（58.90±4.62）%]，차이유통계학의의（P＜0.05）。혈장Gal-3표체수평여좌심방내경정정상관（r=0.612，P＜0.01），여LVEF정부상관（r=-0.389，P＜0.05）。결론심기경사심력쇠갈환자혈장Gal-3적표체수평경고，혈장Gal-3표체수평여기좌심방내경정정상관，여좌심실사혈분수정부상관。
Objective To observe the expression level of galectin-3 (Gal-3) in patients with heart failure after myocardial infarction (MI). Methods The patients (n=60) were divided into old MI group and non-MI group (each n=30) according to their medical history. The cardiac structure and heart function were reviewed by using echocardiogram, and level of plasma Gal-3 was detected by using ELISA. The difference in Gal-3 level was compared between 2 groups and correlation between Gal-3 level and LVEF was analyzed. Results The expression level of Gal-3 was significantly higher in old MI group than that in non-MI group [(28.88±9.78) ng/mL vs. (22.57± 4.59) ng/mL, P<0.05]. LVEF was significantly lower in old MI group than that in non-MI group [(51.38±9.75)%vs. (58.90±4.62)%, P<0.05]. The expression level of Gal-3 was positively correlated to left atrial diameter (r=0.612, P<0.01) and negatively correlated to LVEF (r=-0.389, P<0.05). Conclusion The expression level of Gal-3 is higher in ACS patients, which is positively correlated to left atrial diameter and negatively correlated to LVEF.